Food for thought: the role of appetitive peptides in age-related cognitive decline.
Food for thought: the role of appetitive peptides in age-related cognitive decline.
复制标题
DOI：
10.1016/j.arr.2013.01.009
复制
发表时间：
2013-06
影响因子：
13.1
通讯作者：
Reagan, Lawrence P.
中科院分区：
文献类型：
--
作者：
Fadel, Jim R.;Jolivalt, Corinne G.;Reagan, Lawrence P.
通过它们在下丘脑中的充分描述的作用，食欲肽如胰岛素、食欲素和瘦素被认为是食物摄入、体重和身体组成的重要调节剂。除了这些代谢活动之外，这些肽还关键地参与了从免疫和神经内分泌功能的调节到成瘾行为和生殖的各种各样的活动。胰岛素、食欲素和瘦素的神经活性还包括促进海马突触可塑性和增强认知能力。虽然肥胖和糖尿病等代谢紊乱患者发生认知缺陷、痴呆和阿尔茨海默病（AD）的风险更大，但对导致或促成年龄相关认知下降的潜在机制知之甚少。鉴于这些肽在代谢紊乱中的重要性，因此更关注它们在与衰老相关的认知缺陷中的潜在作用并不奇怪。本综述的目的是描述临床和临床前研究的证据暗示胰岛素，食欲素和瘦素的病因和进展的年龄相关的认知功能下降。总的来说，这些研究支持这样的假设，即瘦素和胰岛素抵抗，通常与下丘脑相关的概念，也适用于海马体。
Through their well described actions in the hypothalamus, appetitive peptides such as insulin, orexin and leptin are recognized as important regulators of food intake, body weight and body composition. Beyond these metabolic activities, these peptides also are critically involved in a wide variety of activities ranging from modulation of immune and neuroendocrine function to addictive behaviors and reproduction. The neurological activities of insulin, orexin and leptin also include facilitation of hippocampal synaptic plasticity and enhancement of cognitive performance. While patients with metabolic disorders such as obesity and diabetes have greater risk of developing cognitive deficits, dementia and Alzheimer’s disease (AD), the underlying mechanisms that are responsible for, or contribute to, age-related cognitive decline are poorly understood. In view of the importance of these peptides in metabolic disorders, it is not surprising that there is a greater focus on their potential role in cognitive deficits associated with aging. The goal of this review is to describe the evidence from clinical and pre-clinical studies implicating insulin, orexin and leptin in the etiology and progression of age-related cognitive decline. Collectively, these studies support the hypothesis that leptin and insulin resistance, concepts normally associated with the hypothalamus, are also applicable to the hippocampus.
登录
查看更多内容
影响因子：
--
作者：
Craft, Suzanne;Baker, Laura D.;Montine, Thomas J.;Minoshima, Satoshi;Watson, G. Stennis;Claxton, Amy;Arbuckle, Matthew;Callaghan, Maureen;Tsai, Elaine;Plymate, Stephen R.;Green, Pattie S.;Leverenz, James;Cross, Donna;Gerton, Brooke
通讯作者：
Gerton, Brooke
影响因子：
5.3
作者：
Abbott, MA;Wells, DG;Fallon, JR
通讯作者：
Fallon, JR
影响因子：
4.2
作者：
Burdo, Joseph R.;Chen, Qi;Schubert, David
通讯作者：
Schubert, David
影响因子：
7.7
作者：
Baskin, DG;Breininger, JF;Schwartz, MW
通讯作者：
Schwartz, MW
影响因子：
16.2
作者：
Borgland, SL;Taha, SA;Bonci, A
通讯作者：
Bonci, A