Photoinduced CO release, cellular uptake and cytotoxicity of a tris(pyrazolyl) methane (tpm) manganese tricarbonyl complex
Photoinduced CO release, cellular uptake and cytotoxicity of a tris(pyrazolyl) methane (tpm) manganese tricarbonyl complex
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DOI：
10.1039/b719075a
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发表时间：
2008-04-21
影响因子：
4.9
通讯作者：
Schatzschneider, Ulrich
中科院分区：
文献类型：
--
作者：
Niesel, Johanna;Pinto, Antonio;Schatzschneider, Ulrich
用CO-释放化合物[Mn（CO）（3）（tpm）] PF 6处理的HT 29结肠癌细胞的细胞活力研究揭示了与已建立的试剂5-氟尿嘧啶（5-FU）相当的显著的光诱导细胞毒性，而保持在黑暗中的对照在高达100 μ M时不受影响。
Cell viability studies of HT29 colon cancer cells treated with the CO-releasing compound [Mn(CO)(3)(tpm)]PF6 revealed a significant photoinduced cytotoxicity comparable to that of established agent 5-fluorouracil (5-FU), while controls kept in the dark were unaffected at up to 100 mu M.