Mechanisms of immune evasion in breast cancer.
Mechanisms of immune evasion in breast cancer.
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DOI：
10.1186/s12885-018-4441-3
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发表时间：
2018-05-11
期刊：
影响因子：
3.8
通讯作者：
Webb TJ
中科院分区：
文献类型：
--
作者：
Bates JP;Derakhshandeh R;Jones L;Webb TJ
肿瘤在发展过程中会发展出多种免疫逃避机制，某些癌症类型天生比其他癌症更善于“隐藏”。随着对肿瘤免疫监视的理解的增加，免疫疗法已成为乳腺癌的一种有前途的治疗策略，尽管在历史上被认为是一种免疫学沉默的肿瘤。某些类型的癌症，如黑色素瘤、膀胱癌和肾细胞癌，已经证明对免疫干预的持久反应，然而，乳腺肿瘤没有显示出相同的疗效。乳腺癌免疫沉默的原因来自于减少免疫识别和其他促进强烈免疫抑制的机制。乳腺癌中的免疫逃避机制定义不清。因此，进一步表征对于开发更好的疗法至关重要。这篇简短的综述将试图深入了解乳腺癌介导的弱免疫原性和免疫抑制的可能原因，并强调目前用于恢复乳腺癌免疫反应的免疫疗法。
Tumors develop multiple mechanisms of immune evasion as they progress, with some cancer types being inherently better at ‘hiding’ than others. With an increased understanding of tumor immune surveillance, immunotherapy has emerged as a promising treatment strategy for breast cancer, despite historically being thought of as an immunologically silent neoplasm. Some types of cancer, such as melanoma, bladder, and renal cell carcinoma, have demonstrated a durable response to immunotherapeutic intervention, however, breast neoplasms have not shown the same efficacy. The causes of breast cancer’s immune silence derive from mechanisms that diminish immune recognition and others that promote strong immunosuppression. It is the mechanisms of immune evasion in breast cancers that are poorly defined. Thus, further characterization is critical for the development of better therapies. This brief review will seek to provide insight into the possible causes of weak immunogenicity and immune suppression mediated by breast cancers and highlight current immunotherapies being used to restore immune responses to breast cancer.
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影响因子：
64.8
作者：
通讯作者：
--
DOI：
10.1084/jem.20050915
发表时间：
2005-12-19
期刊：
The Journal of experimental medicine
影响因子：
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作者：
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影响因子：
45.3
作者：
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影响因子：
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作者：
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影响因子：
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