EFFECTS OF USING DEXAMETHASONE AND PLACEBO IN THE TREATMENT OF PROLAPSED LUMBAR-DISK
EFFECTS OF USING DEXAMETHASONE AND PLACEBO IN THE TREATMENT OF PROLAPSED LUMBAR-DISK
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DOI：
10.1111/j.1600-0404.1982.tb03055.x
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发表时间：
1982-01-01
影响因子：
3.5
通讯作者：
RAMSING, P
中科院分区：
文献类型：
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作者：
HEDEBOE, J;BUHL, M;RAMSING, P
以前的报告关于治疗[疼痛]症状的腰椎间盘突出症与全身管理的强有力的类固醇地塞米松已显示出良好的结果。患者（39）被评估为腰椎间盘突出症，在一项双盲对照研究中接受地塞米松或安慰剂治疗。在20例患者中观察到可证明的治疗效果; 19例无效。19例患者接受地塞米松（13 +效应），20例患者接受安慰剂（7 +效应）。两组完全可比，差异无统计学意义。在3个月的时间内，两组中通过治疗得到改善的患者中，有50%复发，需要手术。地塞米松肌肉注射的效果。在治疗腰椎间盘突出症方面似乎并没有超过安慰剂。
Previous reports concerning the treatment of [pain] symptoms deriving from prolapsed lumbar disk with systemic administration of the potent steroid dexamethasone have shown favorable results. Patients (39) were assessed with symptoms of prolapsed lumbar disk, treated in a controlled double-blind investigation with dexamethasone or placebo. Provable effect of the treatment was seen in 20 patients; 19 had no effect. Nineteen patients received dexamethasone (13 + effect), 20 received placebo (7 + effect). The groups were fully comparable, and the difference was not statistically significant. During a period of 3 mo., 50% of the patients who improved by the treatment in either group had recurrences leading to operation. The effect of dexamethasone given i.m. does not seem to exceed that of placebo in the treatment of prolapsed lumbar disk.