A survey of approaches for direct parametric image reconstruction in emission tomography
A survey of approaches for direct parametric image reconstruction in emission tomography
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DOI：
10.1118/1.2966349
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发表时间：
2008-09-01
期刊：
影响因子：
3.8
通讯作者：
Thielemans, Kris
中科院分区：
文献类型：
--
作者：
Tsoumpas, Charalampos;Turkheimer, Federico E.;Thielemans, Kris
通过发射断层摄影获得的定量数据使用许多技术和方法依次解码以提供生理信息。传统上，数据被重建以产生一系列静态图像。然后，应用药代动力学建模技术，并推导出具有生理或功能意义的动力学参数。虽然可以优化这个过程中的每个估计步骤，但必须引入许多简化假设，以使所使用的方法切实可行。已发表的研究表明，如果直接从测量数据估计动力学参数，则参数图像将具有比间接估计更高的质量和更低的均方误差。这篇评论强调了一些方面的方法，已提出了这样的直接估计的药代动力学信息的原始排放数据。(C)2008年美国医学物理学家协会。
The quantitative data obtained by emission tomography are decoded using a number of techniques and methods in sequence to provide physiological information. Conventionally, the data are reconstructed to produce a series of static images. Then, pharmacokinetic modeling techniques are applied, and kinetic parameters that have physiological or functional significance are derived. Although it is possible to optimize each estimation step in this process, many simplifying assumptions have to be introduced to make the methods that are used practicable. Published research has shown that if the kinetic parameters are estimated directly from the measured data, the parametric images will have higher quality and lower mean-squared error than if this was done indirectly. This review highlights some aspects of the methods that have been proposed for such direct estimation of pharmacokinetic information from raw emission data. (C) 2008 American Association of Physicists in Medicine.