The TDT and other family-based tests for linkage disequilibrium and association.
The TDT and other family-based tests for linkage disequilibrium and association.
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DOI：
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发表时间：
1996-11
影响因子：
9.8
通讯作者：
R. Spielman;W. Ewens
中科院分区：
文献类型：
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作者：
R. Spielman;W. Ewens
传播/不平衡检验（TDT）是Spielman等人几年前提出的，作为复杂疾病与遗传标记之间的连锁检验。TDT的最初用途是在已经发现疾病关联的情况下，检测与候选基因附近的标记的连锁，然而，即使没有先前的关联证据，TDT也是有效的，可以用于检测任何标记（或一组标记），这些标记的数据可以从父母和一个或多个受影响的后代获得。其他的测试也被提出来，这些测试关注的是关联本身，但是像TDT一样，这些测试也适用于核心家庭的数据。此外，最近出现了几篇论文，讨论这些测试和TDT的扩展和属性。由于TDT和关联测试的目的都是定位与疾病易感性有关的基因，因此出现了一些关于它们之间差异的问题。在这篇综述中，我们比较了TDT的属性与那些基于家庭的测试的关联，我们评论的问题，关于使用这些测试。参考文献22篇，2个标签。
The transmission/disequilibrium test (TDT) was introduced several years ago by Spielman et al. as a test for linkage between a complex disease and a genetic marker. The original intended use of the TDT was to test for linkage with a marker located near a candidate gene, in cases where disease association already had been found. However, even if prior evidence for association is absent, the TDT is valid and can be used to test any marker (or a set of markers) for which data are available from parents and one or more affected offspring. Other tests that focus on association itself - but that, like the TDT, are applied to data from nuclear families - also have been proposed. In addition, several papers have appeared recently that discuss extensions and properties of these tests and of the TDT. Since the aim of both the TDT and the association tests is to locate genes that contribute to disease susceptibility, a number of questions about their differences have arisen. In this review, we compare the properties of the TDT with those of family-based tests of association, and we comment on issues regarding the use of these tests. 22 refs., 2 tabs.