Hollow Mesoporous Tantalum Oxide Based Nanospheres for Triple Sensitization of Radiotherapy
Hollow Mesoporous Tantalum Oxide Based Nanospheres for Triple Sensitization of Radiotherapy
复制标题
用于放射治疗三重增敏的空心介孔氧化钽纳米球。
DOI：
10.1021/acsami.9b20053
复制
发表时间：
2020-02-05
影响因子：
9.5
通讯作者：
Li, Yingjia
中科院分区：
文献类型：
--
作者：
Peng, Chao;Liang, Yu;Li, Yingjia
放射治疗(RT)是临床上应用最广泛的肿瘤治疗方法之一，但常发生缺氧相关耐药。为此，构建了聚乙二醇化TaOx载氧纳米平台，用于肿瘤放射治疗的三重增敏。采用原位生长法制备了高Z元素基介孔TaOx中空纳米球，并用氧饱和的全氟戊烷(PFP)对其进行了包裹。近红外激光触发的亚热治疗可增加瘤内血流量，同时释放O-2，提高放疗效率。另一种方法是利用Ta元素将辐射能量沉积在肿瘤内，从而实现放射治疗的三重增敏。体内研究表明，所制备的纳米球可几乎完全抑制肿瘤生长，且无明显副作用，为肿瘤多敏化放射治疗提供了新的可能性。
Radiotherapy (RT) is one of the most widely used cancer treatments in the clinical setting, while hypoxia-associated resistance often occurs. Herein, a PEGylated TaOx-based oxygen-carrying nanoplatform was constructed for triple sensitizing tumor radiotherapy. The high-Z element based hollow mesoporous TaOx nanospheres were prepared following the in situ growth of ultrasmall CuS nanocrystals and then packaged with O-2-saturated perfluoropentane (PFP). NIR laser-triggered mild hyperthermia would lead to the increase of intratumoral blood flow, together with the release of O-2, the radiotherapeutic efficiency would be enhanced. Alternatively, radiant energy would be deposited inside the tumor by the Ta element, therefore triple sensitization of radiotherapy could be achieved. The in vivo studies showed that the as-prepared nanospheres could achieve almost total inhibition of tumor growth without obvious side effects, which provides new possibilities for multisensitizing tumor radiotherapy.