The role of early life viral bronchiolitis in the inception of asthma.
The role of early life viral bronchiolitis in the inception of asthma.
复制标题
DOI：
10.1097/aci.0b013e32835eb6ef
复制
发表时间：
2013-04
影响因子：
2.8
通讯作者：
Bacharier LB
中科院分区：
文献类型：
--
作者：
Beigelman A;Bacharier LB
累积的证据表明，生命早期毛细支气管炎是随后喘息发作和哮喘的主要危险因素。本综述的目的是介绍最近的研究结果和当前的观点之间的相互作用毛细支气管炎和长期的呼吸结果。最近的研究支持了早期严重呼吸道合胞病毒细支气管炎和学龄前哮喘医生诊断之间的长期公认的联系，这种联系似乎持续到成年早期。越来越多的证据表明，生命早期感染人鼻病毒是未来哮喘的重要前因。病毒性细支气管炎是否是未来哮喘的病因或早期表现仍不确定。维生素D状态已成为病毒诱导的喘息的潜在修饰因子，并可能影响哮喘的发展。生命早期的病毒性细支气管炎是随后发生喘息和哮喘的主要和潜在的长期危险因素。毛细支气管炎和随后的哮喘之间的关联是由于因果关系还是易感性的反映可能取决于宿主因素和病毒特异性效应。
Cumulative evidence suggest that early life bronchiolitis is a major risk factor for subsequent wheezing episodes and asthma. The purpose of this review is to present the recent findings and current perspectives regarding the interplay between bronchiolitis and long-term respiratory outcomes. Recent studies have supported the long-recognized link between early life severe Respiratory Syncytial Virus bronchiolitis and the physician diagnosis of asthma by school age, and this association appears to continue into early adulthood. Evidence is accumulating regarding the role of early life infection with human rhinovirus as an important antecedent for future asthma. Whether viral bronchiolitis is causal or an early manifestation of future asthma remains uncertain. Vitamin D status has emerged as a potential modifying factor for viral-induced wheeze and could potentially influence the development of asthma. Viral bronchiolitis early in life is a major and potential long-term risk factor for subsequent wheezing and asthma. Whether the association between bronchiolitis and subsequent asthma is due to causality or a reflection of predisposition may be dependent on host factors and virus-specific effects.