[Molecular epidemiology of cerebrovascular diseases; the Hisayama study and the Fukuoka Stroke Registry (FSR)].
[Molecular epidemiology of cerebrovascular diseases; the Hisayama study and the Fukuoka Stroke Registry (FSR)].
复制标题
[脑血管疾病的分子流行病学；
DOI：
10.5692/clinicalneurol.48.892
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
M. Iida
中科院分区：
文献类型：
--
作者：
T. Kitazono;M. Kubo;J. Hata;S. Ibayashi;Y. Kiyohara;M. Iida
脑卒中的潜在发病机制是由多种环境危险因素以及遗传因素介导的。因此，我们必须准确评估环境因素，以确定卒中相关基因多态性。久山研究是一项心血管疾病的流行病学研究，于1961年在日本久山成立。2002年，在久山市进行了遗传研究的筛选调查。福冈卒中登记（FSR）是以医院为基础的卒中患者登记。来自日本南部8个医疗中心的中风专家参加了FSR。本研究分别从Hisayama研究和FSR中招募对照和病例受试者。我们进行了一项全基因组病例对照研究，发现PRKCH中编码蛋白激酶C （PKCC eta）成员的非同义SNP与脑梗死显著相关。作为候选基因分析，我们研究了NAD (P) H氧化酶C242T多态性在脑梗死发生中的作用。C242T多态性与腔隙性和动脉粥样硬化性血栓性梗死无关；然而，t等位基因的存在可能在心房颤动和心栓性脑梗死的发生中起保护作用。这些研究可能为中风治疗策略的发展提供重要信息。
The underlying pathogenesis of stroke is mediated by a variety of environmental risk factors as well as genetic ones. Thus, we have to evaluate the environmental factors precisely to identify the stroke-related gene polymorphisms. The Hisayama study, an epidemiological study of cardiovascular diseases, was established in 1961 in Hisayama, Japan. In 2002, a screening survey for the genetic study was performed in Hisayama. The Fukuoka Stroke Registry (FSR) is a hospital-based registration of stroke patients. Stroke specialists from eight medical centers in southern Japan have participated in FSR. In the present study, control and case subjects were recruited from the Hisayama study and FSR, respectively. We performed a genome-wide case-control study and found that a nonsynonymous SNP in PRKCH encoding a member of protein kinase C (PKCC eta) was significantly associated with brain infarction. As a candidate gene analysis, we investigated the role of NAD (P) H oxidase C242T polymorphism in the development of brain infarction. The C242T polymorphism was not associated with lacunar and atherothrombotic infarction; however, the presence of T-allele may have a protective role in the occurrence of atrial fibrillation and cardioembolic brain infarction. These studies may provide important information for the development of the therapeutic strategies against stroke.
影响因子：
3.5
作者：
Hata, Jun;Matsuda, Koichi;Kubo, Michiaki
通讯作者：
Kubo, Michiaki