An anatomy of normal and malignant gene expression
An anatomy of normal and malignant gene expression
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DOI：
10.1073/pnas.152324199
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发表时间：
2002-08-20
影响因子：
11.1
通讯作者：
Riggins, GJ
中科院分区：
文献类型：
--
作者：
Boon, K;Osório, EC;Riggins, GJ
基因的表达模式为其在正常生理和疾病中的作用提供了线索。为了在全基因组范围内提供定量的表达水平，癌症基因组解剖计划（CGAP）使用基因表达系列分析（SAGE）技术。已经汇集了来自100多种人类细胞类型的500多万个转录本标签。为了提高这些数据的实用性，CGAP SAGE项目创建了SAGE Genie，这是一个用于分析和展示SAGE数据的网站（http://cgap.nci.nih.gov/SAGE）。SAGE Genie在基因名称和SAGE转录本水平之间提供了自动链接，考虑到了可变转录和许多潜在的错误。这些信息学进展提供了人体或大脑中转录本表达的快速直观视图，展示在SAGE解剖浏览器上。我们在此报告了一种几乎可以轻松获取的、关于任何基因在多种恶性和正常组织中表达的视图。
A gene's expression pattern provides clues to its role in normal physiology and disease. To provide quantitative expression levels on a genome-wide scale, the Cancer Genome Anatomy Project (CGAP) uses serial analysis of gene expression (SAGE). Over 5 million transcript tags from more than 100 human cell types have been assembled. To enhance the utility of this data, the CGAP SAGE project created SAGE Genie, a web site for the analysis and presentation of SAGE data (http://cgap.nci.nih.gov/SAGE). SAGE Genie provides an automatic link between gene names and SAGE transcript levels, accounting for alternative transcription and many potential errors. These informatics advances provide a rapid and intuitive view of transcript expression in the human body or brain, displayed on the SAGE Anatomic Viewer. We report here an easily accessible view of nearly any gene's expression in a wide variety of malignant and normal tissues.