Forecasting the development of primary hepatocellular carcinoma by the use of risk factors: studies in West Africa.
Forecasting the development of primary hepatocellular carcinoma by the use of risk factors: studies in West Africa.
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利用危险因素预测原发性肝细胞癌的发展：西非的研究。
DOI：
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发表时间：
1977
期刊：
影响因子：
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通讯作者：
M. Payet
中科院分区：
文献类型：
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作者：
B. Larouzé;B. Blumberg;W. London;E. Lustbader;M. Sankalé;M. Payet
B型肝炎病毒（HBV）和原发性肝细胞癌（PHC）之间的关联已在非洲、亚洲和其他地方的几项研究中发现。在本文中，我们考虑了几个事件之间的相互关系，这些事件包括：1）B肝炎表面抗原（HBsAg），2）B肝炎核心抗原抗体（抗-HBc），3）表面抗原抗体（抗-HBs），4）慢性肝病，5）甲胎蛋白升高，6）PHC。使用初步的流行病学数据，计算与这些事件相关的危险因素。我们建议，这些事件之间的相互作用和HBV感染的父母被用来估计在这种环境中的个人肝癌的风险。
An association between hepatitis B virus (HBV) and primary hepatocellular carcinoma (PHC) has been found in several studies in Africa, Asia, and elsewhere. In this paper we considered the interrelations between several events related to HBV infection, which include the presence of: 1) hepatitis B surface antigen (HBsAg), 2) antibody to hepatitis B core antigen (anti-HBc), 3) antibody to the surface antigen (anti-HBs), 4) chronic liver disease, 5) elevated alpha-fetoprotein, and 6) PHC. With the use of preliminary epidemiologic data, risk factors related to these events were calculated. We suggested that the interactions between these events and HBV infection in parents be used to estimate the risk of PHC for an individual in this environment.