Allergic contact sensitization in an unselected Danish population. The Glostrup Allergy Study, Denmark.
Allergic contact sensitization in an unselected Danish population. The Glostrup Allergy Study, Denmark.
复制标题
未经选择的丹麦人群的过敏性接触致敏。
作者：
N. H. Nielsen;T. Menné
在居住在丹麦哥本哈根西部的未选择人群中评估了过敏性接触致敏的分布。包括23种半抗原和半抗原混合物的即用型贴片测试邮寄给793名成年人，567人（71.5%）参加了测试。应用后2天进行测试。86例（15.2%）被试出现111例阳性反应。男性致敏率低于女性（11.5%对18.8%）。在测试的23种化学物质中，有20种引起了积极的反应。对镍和硫柳汞的阳性反应最为常见（分别为6.7%和3.4%）。其他化学物质的频率为1.1%或更少。男性对镍的敏感性低于女性（2.2%对11.1%）。敏化的频率可能代表最低数字。需要考虑对暴露进行调节，以防止已致敏者的原发性致敏和疾病复发。
The distribution of allergic contact sensitization was assessed in an unselected population, living in western Copenhagen, Denmark. Ready-to-apply patch tests comprising 23 haptens and mixtures of haptens were mailed to 793 adults, and 567 (71.5%) participated. The tests were read 2 days after application. A total of 111 positive reactions were found among 86 (15.2%) subjects. Sensitization was less frequent in men than in women (11.5% versus 18.8%). Twenty out of the 23 chemicals in the test elicited positive reactions. Positive reactions to nickel and thiomersal were found most frequently (6.7% and 3.4%, respectively). Concerning the other chemicals the frequencies were 1.1% or less. Nickel sensitivity was less frequent in men than in women (2.2% versus 11.1%). The frequencies of sensitization probably represent minimum figures. Regulation of exposure needs to be considered in order to prevent primary sensitization and disease recurrences in those already sensitized.