BRONCHOALVEOLAR LAVAGE FOR THE PREPARATION OF FREE LUNG-CELLS - TECHNIQUE AND COMPLICATIONS
BRONCHOALVEOLAR LAVAGE FOR THE PREPARATION OF FREE LUNG-CELLS - TECHNIQUE AND COMPLICATIONS
复制标题
DOI：
10.1016/0007-0971(80)90055-8
复制
发表时间：
1980-01-01
期刊：
影响因子：
--
通讯作者：
COLLINS, J
中科院分区：
文献类型：
--
作者：
COLE, P;TURTON, C;COLLINS, J
在纤维支气管镜检查中进行支气管肺泡灌洗，可以对外周支气管肺泡游离细胞群（主要由淋巴细胞和巨噬细胞组成）进行采样。产量是足够的详细的形态和功能的调查，这些细胞，可以通过利用巨噬细胞的玻璃粘附或吞噬特性分离。这些研究特别感兴趣的是，在复发性胸部感染的患者中，检测局部细胞免疫的异常;在肺纤维化中，通过观察游离肺细胞的形态学和测试功能来评估疾病的活动和治疗效果;以及在支气管癌中，调查对肿瘤的局部免疫反应。在这种情况下，该程序被认为是合乎道德的。灌洗包括通过光导纤维支气管镜用高达500 ml pH校正的生理盐水溶液冲洗节段支气管。有呼吸或心脏风险的患者禁用，但大多数患者耐受良好。并发症包括急性呼吸窘迫、血管迷走性晕厥和发热伴肺浸润。灌洗与PaO 2 [动脉O2压]平均下降3.0 kPa [千帕斯卡单位]（22.7 mm Hg）相关，建议常规补充O2。
Bronchoalveolar lavage at fibreoptic bronchoscopy enables the peripheral bronchoalveolar free cell population, which consists mainly of lymphocytes and macrophages, to be sampled. The yield is sufficient for detailed morphological and functional investigation of these cells, which can be separated by exploiting the glass-adherent or phagocytic properties of macrophages. Such studies are of particular interest in patients with recurrent chest infections, to detect abnormalities of local cellular immunity; in pulmonary fibrosis, to assess activity of the disease and effect of treatment by observing morphology and testing function of free lung cells; and in bronchial carcinoma, to investigate local immune responses to the tumour. The procedure is held to be ethical in these circumstances. The lavage consists of irrigation of a segmental bronchus through the fibreoptic bronchoscope with up to 500 ml pH-corrected normal saline solution. It is contraindicated in those with respiratory or cardiac risk, but is tolerated well by most patients. Complications include acute respiratory distress, vasovagal syncope and fever with pulmonary infiltrates. Lavage is associated with a mean fall of PaO2 [arterial O2 pressure] of 3.0 kPa [kilo pascal unit] (22.7 mm Hg) and routine O2 supplementation is recommended.