Relationship between orthostatic hypotension and cognitive impairment in the elderly
Relationship between orthostatic hypotension and cognitive impairment in the elderly
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DOI：
10.1016/j.jns.2010.08.056
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发表时间：
2010-12-15
影响因子：
4.4
通讯作者：
Hanon, Olivier
中科院分区：
文献类型：
--
作者：
Mehrabian, Shima;Duron, Emmanuelle;Hanon, Olivier
背景与目的：探讨老年记忆障碍患者体位性低血压（OH）与认知功能的关系。方法：我们研究了在记忆中心连续就诊的495名老年门诊患者的认知功能与OH之间的关系。在坐着和站着时测量血压（BP）。我们使用一套经过验证的综合神经心理学测试来检查认知功能，认知效率概况（CEP）评估主要的认知区域。根据受试者的认知状态将其分为正常认知功能、轻度认知障碍（MCI）、阿尔茨海默病（AD）和血管性痴呆（VaD） 4类。结果：在该人群中，76 +/- 8岁（女性72%），18%认知功能正常，28%轻度认知障碍，47% AD, 7% VaD。74%的患者出现高血压。14%的受试者（n = 69）存在OH。在调整了年龄、受教育程度、收缩压、舒张压、体重和抗高血压药物等因素后，OH患者的认知功能较无OH患者差（CEP评分50 24比56 22，p . 1）
Background and purpose: To determine the relationship between orthostatic hypotension (OH) and cognitive function in elderly subjects with memory complaints.Methods: We studied the association between cognitive function and OH in 495 consecutive elderly outpatients attending a memory centre. Blood pressure (BP) was measured in a sitting and standing position. We examined cognitive function using a validated comprehensive battery of neuropsychological tests, the cognitive efficiency profile (CEP) assessing the main cognitive areas. Subjects were classified into 4 categories according to their cognitive status: normal cognitive function, mild cognitive impairment (MCI), Alzheimer's disease (AD) or vascular dementia (VaD).Results: In this population, 76 +/- 8 years of age (women 72%), 18% had normal cognitive function, 28% had MCI, 47% AD, and 7% VaD. Hypertension was observed in 74% of patients. OH was present in 14% of subjects (n = 69). After adjustment for age, education level, systolic BP, diastolic BP, weight, and antihypertensive drugs, subjects with OH had worse cognitive function than those without OH (CEP score 50 24 vs 56 22, p