H7N9 avian influenza A virus in China: a short report on its circulation, drug resistant mutants and novel antiviral drugs.
H7N9 avian influenza A virus in China: a short report on its circulation, drug resistant mutants and novel antiviral drugs.
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中国H7N9甲型禽流感病毒：关于其传播、耐药突变体和新型抗病毒药物的简短报告
DOI：
10.1080/14787210.2017.1353419
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发表时间：
2017-08
影响因子：
5.7
通讯作者：
Richt JA
中科院分区：
文献类型：
--
作者：
Danqi B;Li Z;Liu Q;Richt JA
ABSTRACT Introduction: The first human H7N9 avian influenza virus case was reported in Shanghai in 2013. Shortly thereafter, this virus spread to other regions in China. Molecular analysis indicated that the H7N9 virus is a reassortant virus containing internal genes from the H9N2 virus and previously described mammalian adaption markers, which could allow the virus to adapt efficiently to a mammalian host. Fortunately, there is no evidence of sustained person-to-person spread. Most of the human H7N9 cases have a history of exposure to live poultry markets (LPMs). The circulating H7N9 were low pathogenic viruses, however highly pathogenic H7N9 viruses were recently identified in human cases. Areas covered: In the present article, the circulation of H7N9 in LPMs of China, the five waves of H7N9 infection in humans, recently identified drug resistant mutants and potential antiviral drugs against H7N9 are discussed; this may provide further understanding of the evolution and pandemic potential of the H7N9 influenza viruses. Expert commentary: All the data reveal that the major source of H7N9 viruses are LPMs and the H7N9 virus is still circulating widely in China. It is concerning that the recent emergence of highly pathogenic H7N9 viruses may result in highly transmissible viruses in mammalian species.
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人类感染新型禽源甲型流感 (H7N9) 病毒。
影响因子：
158.5
作者：
Gao, Rongbao;Cao, Bin;Shu, Yuelong
通讯作者：
Shu, Yuelong
影响因子：
1.4
作者：
Li Y;Huang XM;Zhao DM;Liu YZ;He KW;Liu YX;Chen CH;Long LP;Xu Y;Xie XX;Han KK;Liu XY;Yang J;Zhang YF;Fan F;Webby R;Wan XF
通讯作者：
Wan XF
影响因子：
11.8
作者：
Fan M;Huang B;Wang A;Deng L;Wu D;Lu X;Zhao Q;Xu S;Havers F;Wang Y;Wu J;Yin Y;Sun B;Yao J;Xiang N
通讯作者：
Xiang N
影响因子：
7.6
作者：
Furuta, Yousuke;Gowen, Brian B.;Takahashi, Kazumi;Shiraki, Kimiyasu;Smee, Donald F.;Barnard, Dale L.
通讯作者：
Barnard, Dale L.
影响因子：
4.9
作者：
Sleeman, Katrina;Mishin, Vasiliy P.;Gubareva, Larisa V.
通讯作者：
Gubareva, Larisa V.