Right ventricular sugars and fats in chronic thromboembolic pulmonary hypertension.
Right ventricular sugars and fats in chronic thromboembolic pulmonary hypertension.
复制标题
慢性血栓栓塞性肺动脉高压中的右心室糖和脂肪。
DOI：
10.1016/j.ijcard.2016.06.010
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Tatsumi K.
中科院分区：
文献类型：
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作者：
Sakao S;Daimon M;Voelkel NF;Miyauchi H;Jujo T;Sugiura T;Ishida K;Tanabe N;Kobayashi Y;Tatsumi K.
背景/目的一些研究已经显示右心室（RV）血流动力学值分别与RV中葡萄糖摄取或脂肪酸摄取之间的相关性。然而，很少有研究比较肺动脉高压治疗前后右心室代谢的变化。本研究的目的是评估慢性血栓栓塞性肺动脉高压（CTEPH）患者在肺血栓动脉内膜切除术前后的右心室葡萄糖和脂肪酸，并检查右心室葡萄糖和脂肪酸摄取之间是否存在相关性。CTEPH患者术前行[18 F]氟-2-脱氧葡萄糖（FDG）-正电子发射断层扫描（PET）和123 I-β-甲基碘苯基十五烷酸（BMIPP）显像，结果PEA术后患者右室[18F] FDG摄取和123 I-BMIPP摄取均明显降低（P < 0.01）。[18F] FDG摄取与123 I-BMIPP摄取亦呈显著相关（r = 0.45，p = 0.04）。尽管应激RV能量代谢改变的确切细节尚不清楚，但这是第一项评价CTEPH患者血栓动脉内膜切除术前后葡萄糖和脂肪酸摄取的研究，尽管患者数量有限。
Background/objectivesSeveral studies have already shown the correlation between the right ventricle (RV) hemodynamic values and either glucose uptake or fatty acid uptake in the RV, respectively. However, there are few studies to compare the RV metabolic alteration before and after treatment for pulmonary hypertension. The aims of this study are to assess right ventricular glucose and fatty acid in chronic thromboembolic pulmonary hypertension (CTEPH) patients before and after pulmonary thromboendarterectomy and to examine whether there is a correlation between right ventricular glucose and fatty acid uptake.MethodsTo assess glucose and fatty acid accumulation in the RV, [18F] fluoro-2-deoxyglucose (FDG)-positron emission tomography (PET) and123I-β-methyl iodophenyl pentadecanoic acid (BMIPP) imaging were performed in CTEPH patients before (FDG: n = 20, BMIPP: n = 13) and after (FDG: n = 12, BMIPP: n = 8) thromboendarterectomy.ResultsBoth [18F] FDG uptake and123I-BMIPP uptake in RV of post-PEA patients obviously decreased after this operation procedure (p < 0.01). The right ventricle [18F] FDG uptake was also significantly correlated with123I-BMIPP uptake (r = 0.45, p = 0.04).ConclusionsIn this study, we observed that both glucose and fatty acid accumulated in the RV of patients with CTEPH. Although the exact details of the altered energy metabolism in the stressed RV remain unknown, this is the first study to evaluate both glucose and fatty acid uptake before and after thromboendarterectomy in patients with CTEPH, even though the number of the patient is limited.