T-cell subsets in schizophrenia: a comparison between drug-naive first episode patients and chronic schizophrenic patients
T-cell subsets in schizophrenia: a comparison between drug-naive first episode patients and chronic schizophrenic patients
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DOI：
10.1016/s0920-9964(98)00175-3
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发表时间：
1999-07
影响因子：
4.5
通讯作者：
B. Sperner-Unterweger;A. Whitworth;G. Kemmler;W. Hilbe;J. Thaler;G. Weiss;W. Fleischhacker
中科院分区：
文献类型：
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作者：
B. Sperner-Unterweger;A. Whitworth;G. Kemmler;W. Hilbe;J. Thaler;G. Weiss;W. Fleischhacker
本文对56例精神分裂症急性期患者的T细胞亚群（CD_（3+）、CD_（4+）、CD_（8+）、NK细胞）及CD_（4+）/CD_（8+）比值进行了测定。对35例慢性精神分裂症患者和21例首发精神分裂症患者进行了比较研究，并与16例健康对照者进行了比较。在疾病的急性状态（第0天）、治疗7天后和出院时定量T细胞亚群。在急性状态下，与健康对照组相比，精神分裂症患者显示出更高的CD 3+和CD 4+细胞（p=0.05）以及更高的CD 4/CD 8比率（p=0.02），而NK细胞则较低（p=0.05）。在首次发作患者中，所有T细胞改变在治疗期间恢复正常。在慢性组中，该比率仍然很高，而最初较低的NK细胞数量随着时间的推移而正常化。这些研究结果，支持免疫系统失调的精神分裂症，讨论有关的精神病理学，疾病的阶段和药物的影响。
T-cell subsets (CD3+, CD4+, CD8+, NK-cells) and the CD4+/CD8+ ratio were measured in 56 schizophrenic patients admitted to hospital with an acute psychosis. Thirty-five patients with chronic schizophrenia and 21 drug-naive first episode schizophrenic patients were compared with 16 healthy controls. T-cell subsets were quantified in the acute state of the illness (day 0), after 7 days of treatment and at the time of discharge. In the acute state, schizophrenic patients showed higher CD3+ and CD4+ cells (p=0.05) and a higher CD4/CD8 ratio (p=0.02) than healthy controls, while NK-cells were lower (p=0.05). In first episode patients, all T-cell alterations normalized during treatment. In the chronic group the ratio remained high, whereas the initially low number of NK-cells normalized over time. These findings, supporting immune sytem dysregulation in schizophrenia, are discussed in relation to psychopathology, the stage of illness and effects of medication.