Are the n-3 fatty acids from dietary fish oil deposited in the triglyceride stores of adipose tissue?
Are the n-3 fatty acids from dietary fish oil deposited in the triglyceride stores of adipose tissue?
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DOI：
10.1093/ajcn/51.4.535
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发表时间：
1990-04
期刊：
影响因子：
--
通讯作者：
D. S. Lin;W. Conner
中科院分区：
文献类型：
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作者：
D. S. Lin;W. Conner
脂肪组织是必需脂肪酸（n-3和n-6）的主要储存库。为了研究膳食n-3脂肪酸二十碳五烯酸（EPA）（20：5）和二十二碳六烯酸（DHA）（22：6）以及独特的单不饱和脂肪酸鲸蜡油酸（22：1 n-11）向脂肪组织中的掺入，给兔子喂食两种不同的加工鱼油：MaxEPA（高EPA和DHA; Seven Sea Ltd，船体，英国）和鲱鱼油（高鲸蜡油酸）。EPA和DHA从对照组家兔脂肪组织中占总脂肪组织脂肪酸的0%分别增加至MaxEPA喂养家兔中的2.2%和4.9%。脂肪组织中DHA与EPA的比例高于饮食中的DHA与EPA的比例，表明EPA的替代代谢途径。在喂食鲱鱼油的兔子的脂肪组织中，鲸蜡酸占总脂肪酸的比例从0%增加到7.9%。EPA和DHA的沉积量分别为1.8%和2.8%。我们的数据表明，这些独特的长链不饱和脂肪酸从膳食鱼油很容易纳入脂肪储存，从那里他们可以动员。
Adipose tissue is the chief reservoir of the essential fatty acids (n-3 and n-6). To study the incorporation of the dietary n-3 fatty acids eicosapentaenoic acid (EPA) (20:5) and docosahexaenoic acid (DHA) (22:6), and a unique monounsaturated fatty acid, cetoleic acid (22:1n-11), into adipose tissue, rabbits were fed two different processed fish oils: MaxEPA (high in EPA and DHA; Seven Sea Ltd, Hull, UK) and herring oil (high in cetoleic acid). EPA and DHA increased from 0% of total adipose tissue fatty acid, in the adipose tissue of control rabbits to 2.2% and 4.9%, respectively, in MaxEPA-fed rabbits. The DHA-to-EPA ratio in the adipose tissue was higher than that in the diet, indicating alternative metabolic pathways for EPA. In the adipose tissue of herring-oil-fed rabbits, cetoleic acid increased from 0% to 7.9% of total fatty acids. The deposition of EPA and DHA was 1.8% and 2.8%, respectively. Our data indicated that these unique long-chain unsaturated fatty acids from dietary fish oils were readily incorporated into the fat stores from whence they could be mobilized.