Hybridization of carboxymethyl chitosan with MOFs to construct recyclable, long-acting and intelligent antibacterial agent carrier
Hybridization of carboxymethyl chitosan with MOFs to construct recyclable, long-acting and intelligent antibacterial agent carrier
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DOI：
10.1016/j.carbpol.2020.115848
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发表时间：
2020-04-01
影响因子：
11.2
通讯作者：
Lin, Baofeng
中科院分区：
文献类型：
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作者：
Huang, Guohuan;Li, Yanming;Lin, Baofeng
本研究提出了一种将羧甲基壳聚糖(CMCS)与HKUST-1交织在一起的新策略，以构建生态友好、可回收、长效、智能的HKUST-1@CMCS抗菌剂载体。联合表征表明，通过不同强度的磷酸盐刺激，HKUST-1@CMCS的结构被逐步破坏，从而实现了抗菌剂的智能释放。结果表明，负载富马酸二甲酯的HKUST-1@CMCS比单纯的富马酸二甲酯具有更强的智能和长效(384h，0.04MPBS)的释放性能，在磷酸盐刺激下7d对金黄色葡萄球菌的抑菌圈直径分别为17.4+/-0.1，10.2+/-0.7 mm，而单纯的富马酸二甲酯在2d就失去了抗菌活性，具有优越的长效抗菌活性，可以有效地延长草莓作为食品包装的货架期。此外，HKUST-1@CMCs很容易再生，再生后的HKSUT-1@CMCs在一个周期内仍保持智能响应特性。
This study posed a novel strategy of interweaving carboxymethyl chitosan (CMCS) and HKUST-1 to build eco-friendly, recyclable, long-acting and intelligent antibacterial agent carrier of HKUST-1@CMCS. Combined characterizations revealed that the structure of HKUST-1@CMCS was destroyed step by step through different intensity of the stimulation of phosphate, thereby realizing intelligent release of antibacterial agent. The results showed that dimethyl fumarate-loaded HKUST-1@CMCS was much intelligent and long-acting (384 h, 0.04M PBS) release performance than pure dimethyl fumarate, thus its inhibition zone diameters with and without stimulation of phosphate on S. aureus were 17.4 +/- 0.1, 10.2 +/- 0.7mm at 7 d, respectively, while that of pure dimethyl fumarate had lost antibacterial activity at 2 d. With superior and long-acting antimicrobial activity, dimethyl fumarate-loaded HKUST-1@CMCS could effectively prolong the shelf life of strawberries as food packaging. Furthermore, HKUST-1@CMCS could easily regenerate, and regenerated HKSUT-1@CMCS still maintained intelligent response property at one cycle.