Relevance of Vitamin D in Melanoma Development, Progression and Therapy
Relevance of Vitamin D in Melanoma Development, Progression and Therapy
复制标题
DOI：
10.21873/anticanres.13976
复制
发表时间：
2020-01-01
影响因子：
2
通讯作者：
Slominski, Andrzej T.
中科院分区：
文献类型：
--
作者：
Brozyna, Anna A.;Hoffman, Robert M.;Slominski, Andrzej T.
黑色素瘤是最致命的皮肤癌之一，一旦疾病进入转移，预后很差。目前针对晚期黑色素瘤的治疗方案疗效低、价格昂贵且副作用严重。因此，需要开发新的治疗方案。皮肤细胞能够通过经典和非经典途径激活维生素 D。维生素 D 衍生物具有促进分化和抑制增殖的抗癌特性。由于流行病学研究尚不明确，全身维生素 D 在黑色素瘤患者中的作用尚不清楚。相比之下，实验数据清楚地表明维生素D及其衍生物具有抗黑色素瘤的特性。此外，分子和临床病理学研究已证明维生素 D 信号传导缺陷与黑色素瘤进展和疾病结果之间存在相关性。因此，充足的维生素D信号传导可以在黑色素瘤的治疗中发挥作用。
Melanoma is one of the most lethal types of skin cancer, with a poor prognosis once the disease enters metastasis. The efficacy of currently available treatment schemes for advanced melanomas is low, expensive, and burdened by significant side-effects. Therefore, there is a need to develop new treatment options. Skin cells are able to activate vitamin D via classical and non-classical pathways. Vitamin D derivatives have anticancer properties which promote differentiation and inhibit proliferation. The role of systemic vitamin D in patients with melanoma is unclear as epidemiological studies are not definitive. In contrast, experimental data have clearly shown that vitamin D and its derivatives have anti-melanoma properties. Furthermore, molecular and clinicopathological studies have demonstrated a correlation between defects in vitamin D signaling and progression of melanoma and disease outcome. Therefore, adequate vitamin D signaling can play a role in the treatment of melanoma.