Risk factors for adverse life outcomes in fetal alcohol syndrome and fetal alcohol effects
Risk factors for adverse life outcomes in fetal alcohol syndrome and fetal alcohol effects
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DOI：
10.1097/00004703-200408000-00002
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发表时间：
2004-08-01
影响因子：
2.4
通讯作者：
Young, JK
中科院分区：
文献类型：
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作者：
Streissguth, AP;Bookstein, FL;Young, JK
胎儿酒精综合症 (FAS) 和胎儿酒精效应 (FAE) 患者的临床描述表明，他们在适应行为方面存在重大问题。通过对 415 名 FAS 或 FAE 患者（中位年龄 14 岁，范围 6-51；中位智商 86，范围 29-126）的生活史访谈，检查了 5 种操作上定义的不良结果和 18 种相关风险/保护因素。这些患者中有百分之八十不是由其亲生母亲抚养长大的。对于青少年和成年人，一生中经历过学校经历中断的患病率为 61%，触犯法律的患病率为 60%，监禁（拘留所、看守所、监狱或精神病院或酒精/毒品住院环境）的患病率为 50%，反复发生不当性行为的患病率为 49%，酒精/毒品问题的患病率为 35%。通过在较早的年龄接受 FAS 或 FAE 的诊断并在良好稳定的环境中长大，避免这些不良生活后果的几率会增加 2 至 4 倍。
Clinical descriptions of patients with Fetal Alcohol Syndrome (FAS) and Fetal Alcohol Effects (FAE) suggest major problems with adaptive behavior. Five operationally defined adverse outcomes and 18 associated risk/protective factors were examined using a Life History Interview with knowledgeable informants of 415 patients with FAS or FAE (median age 14 years, range 6-51; median IQ 86, range 29-126). Eighty percent of these patients were not raised by their biological mothers. For adolescents and adults, the life span prevalence was 61% for Disrupted School Experiences, 60% for Trouble with the Law, 50% for Confinement (in detention, jail, prison, or a psychiatric or alcohol/drug inpatient setting), 49% for Inappropriate Sexual Behaviors on repeated occasions, and 35% for Alcohol/Drug Problems. The odds of escaping these adverse life outcomes are increased 2- to 4-fold by receiving the diagnosis of FAS or FAE at an earlier age and by being reared in good stable environments.