Altitude Hypoxia Increases Glucose Uptake in Human Heart
Altitude Hypoxia Increases Glucose Uptake in Human Heart
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DOI：
10.1089/ham.2008.1064
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发表时间：
2009-03-01
影响因子：
2.1
通讯作者：
Kuo, Chia-Hua
中科院分区：
文献类型：
--
作者：
Chen, Chi-Hsien;Liu, Yuh-Feng;Kuo, Chia-Hua
Chen、Chi-Hsien、Yuh-Feng Liu、Shin-Da Lee、Wen-Chih Lee、Ying-Lan Tsai、Chien-Wen Hou、Chih-Yang Huang 和 Chia-Huo Kuo。高原缺氧会增加人体心脏对葡萄糖的摄取。高Alt。医学生物学。 10:83-86, 2009.-心肌是一种高氧组织，主要通过脂肪氧化产生 ATP。然而，当需氧量超过供氧量时，对碳水化合物底物的能量依赖对于维持正常的心脏功能变得至关重要。在这项研究中，首次在模拟海拔条件（14% O-2，相当于海拔 3000 米）或室内空气（21% O-2）下使用[18F]-2-脱氧-2-氟-D-葡萄糖正电子发射断层扫描（FDG-PET）确定了急性高原缺氧对人心脏循环中葡萄糖摄取的影响。我们的结果表明，受试者 (n = 6) 在大约 45 分钟后开始难以维持缺氧状态。与此同时，血乳酸浓度显着增加，这反映了无氧糖酵解速率的加快。缺氧使心脏中的 FDG 摄取量增加了约 70%，但四肢（主要代表骨骼肌）、大脑和肝脏中的 FDG 摄取量没有增加。这项研究为心脏缺氧刺激葡萄糖摄取提供了第一个人类证据。在这种缺氧水平下，先前观察到的大鼠骨骼肌缺氧刺激的葡萄糖摄取在人体研究中并未得到证实。
Chen, Chi-Hsien, Yuh-Feng Liu, Shin-Da Lee, Wen-Chih Lee, Ying-Lan Tsai, Chien-Wen Hou, Chih-Yang Huang, and Chia-Hua Kuo. Altitude hypoxia increases glucose uptake in human heart. High Alt. Med Biol. 10:83-86, 2009.-Cardiac muscle is a highly oxygenated tissue that produces ATP mainly from fat oxidation. However, when the rate of oxygen demand exceeds oxygen supply, energy reliance on the carbohydrate substrate becomes crucial for sustaining normal cardiac function. In this study, the effect of acute altitude hypoxia on glucose uptake from circulation was determined, for the first time, in the human heart, using [18F]-2-deoxy-2-fluoro-D-glucose positron emission tomography (FDG-PET) in a simulated altitude condition (14% O-2, corresponding to similar to 3000 m above sea level) or room air (21% O-2). Our results showed that subjects (n = 6) started to experience difficulty in sustaining the hypoxic condition at similar to 45 min. This was concurrent with a substantially increased blood lactate concentration, which reflects an accelerated rate of anaerobic glycolysis. Hypoxia elevated FDG uptake above control by similar to 70% in heart, but not in limbs (representing primarily skeletal muscle), brain, and liver. This study provides the first human evidence for the hypoxia-stimulated glucose uptake in heart. At this hypoxia level, the previously observed hypoxia-stimulated glucose uptake in rat skeletal muscle was not confirmed in the human study.