Individual differences in reward drive predict neural responses to images of food
Individual differences in reward drive predict neural responses to images of food
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DOI：
10.1523/jneurosci.0350-06.2006
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发表时间：
2006-05-10
影响因子：
5.3
通讯作者：
Calder, Andrew J.
中科院分区：
文献类型：
--
作者：
Beaver, John D.;Lawrence, Andrew D.;Calder, Andrew J.
一个相互关联的大脑区域网络，包括眼眶前额区、腹侧纹状体、杏仁核和中脑区，已被广泛涉及到食物奖励的许多方面。然而，在人类中，每个人对奖励的敏感度可能会有很大的差异。高这一特征的人会经历更频繁和更强烈的食物渴望，更有可能超重或患上与过量食物摄入有关的饮食障碍。使用功能磁共振成像，我们报告了在前额纹状体-杏仁核-中脑网络中，个体特征奖励敏感性的差异(由行为激活量表测量)与对开胃食物(如巧克力蛋糕、披萨)图像的激活高度相关。我们的发现表明，健康参与者对食物暗示的神经反应存在相当大的个性相关变异性，并为揭示某些饮食问题(例如，高摄食性肥胖)潜在的神经生物学因素提供了重要的洞察。
A network of interconnected brain regions, including orbitofrontal, ventral striatal, amygdala, and midbrain areas, has been widely implicated in a number of aspects of food reward. However, in humans, sensitivity to reward can vary significantly from one person to the next. Individuals high in this trait experience more frequent and intense food cravings and are more likely to be overweight or develop eating disorders associated with excessive food intake. Using functional magnetic resonance imaging, we report that individual variation in trait reward sensitivity (as measured by the Behavioral Activation Scale) is highly correlated with activation to images of appetizing foods (e.g., chocolate cake, pizza) in a fronto-striatal-amygdala-midbrain network. Our findings demonstrate that there is considerable personality-linked variability in the neural response to food cues in healthy participants and provide important insight into the neurobiological factors underlying vulnerability to certain eating problems (e.g., hyperphagic obesity).