A three-dimensional population balance model of granulation with a mechanistic representation of the nucleation and aggregation phenomena
A three-dimensional population balance model of granulation with a mechanistic representation of the nucleation and aggregation phenomena
复制标题
粒化的三维群体平衡模型，具有成核和聚集现象的机械表示
DOI：
10.1016/j.ces.2007.07.048
复制
发表时间：
2008
影响因子：
4.7
通讯作者：
J. Litster
中科院分区：
文献类型：
--
作者：
J. M. Poon;C. D. Immanuel;F. Doyle;J. Litster
本文讨论了基于三维种群平衡的湿造粒综合模型，试图捕捉颗粒级现象及其对种群级行为的影响。种群分布的三个维度是粒径、粘结剂含量和颗粒的孔隙率。在种群平衡的表述中，这三种颗粒特性用颗粒的固体体积、液体体积和气体体积三个等效特性来表示。该模型考虑了润湿、成核、聚集和固结现象。机械核的聚集和成核，采用理论对这些粒子水平的微观现象，已经在先前的研究中得到验证。三维人口平衡的数值解决使用有限体积为基础的分解算法，也称为分层两层解决策略[Pinto， m.a., Immanuel, c.d., Doyle III, f.j., 2007。高维人口平衡模型的一种可行求解技术。计算机与化学工程，31,1242-1256]。
A comprehensive model is discussed for wet granulation based on a three-dimensional population balance, as an attempt to capture particle-level phenomena and their influence on the population-level behaviour. The three dimensions of population distribution are the particle size, binder content, and porosity of the granules. In formulating the population balance, these three particle traits are represented in terms of three equivalent traits, namely, the solid volume, liquid volume and gas volume of the granules. The model accounts for wetting, nucleation, aggregation and consolidation phenomena. Mechanistic kernels are derived for aggregation and nucleation, employing theories on these particle-level microscale phenomena that have already been validated in previous studies. The three-dimensional population balance is solved numerically using a finite volume-based decomposition algorithm also called the hierarchical two-tier solution strategy [Pinto, M.A., Immanuel, C.D., Doyle III, F.J., 2007. A feasible solution technique for higher-dimensional population balance models. Computers and Chemical Engineering, 31, 1242–1256].