QUANTITATIVE-ANALYSIS OF CARDIAC-MUSCLE CELL DISORGANIZATION IN THE VENTRICULAR SEPTUM OF PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY
QUANTITATIVE-ANALYSIS OF CARDIAC-MUSCLE CELL DISORGANIZATION IN THE VENTRICULAR SEPTUM OF PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY
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DOI：
10.1161/01.cir.59.4.689
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发表时间：
1979-01-01
期刊：
影响因子：
37.8
通讯作者：
ROBERTS, WC
中科院分区：
文献类型：
--
作者：
MARON, BJ;ROBERTS, WC
肥厚型心肌病患者的特征之一是室间隔内心肌细胞排列异常。为了确定这一组织学标志物对肥厚型心肌病患者的特异性，采用了一种定量的方法来确定无组织细胞所占据的心肌面积。在肥厚型心肌病中，54例尸检患者中有94%出现间隔紊乱。大多数患者存在广泛的组织紊乱，涉及.横切面组织切片占5%，占89%。25%的患者中有56%的患者。在与左心室长轴垂直的组织切片中，间隔紊乱的诊断效果最好。在144名患有其他心脏病或正常心脏的对照患者中，有26%的患者存在间隔紊乱。这些患者的组织紊乱通常程度有限。在7%的对照组中，异常排列的细胞占组织切片的5%或更多。房间隔平均面积为31.+-。3%(平均+-肥厚型心肌病患者的平均标准差)和1.5+-。对照组(P<；0.001)为0.6%。虽然室间隔紊乱不是肥厚型心肌病的病因学特征，但这种异常的广泛分布是该疾病非常敏感和特异的组织学标志。
Abnormally arranged cardiac muscle cells in the ventricular septum was considered a characteristic feature of patients with hypertrophic cardiomyopathy. To determine the specificity of this histologic marker for patients with hypertrophic cardiomyopathy, a quantitative method was used to determine the area of myocardium occupied by disorganized cells. In hypertrophic cardiomyopathy, septal disorganization was present in 94% of 54 patients studied at necropsy. Disorganization was extensive in most patients, involving .gtoreq. 5% of the transverse plane tissue section in 89% and .gtoreq. 25% of the section in 56% of the patients. Septal disorganization was best identified in tissue sections cut perpendicular to the long axis of the left ventricle. Septal disorganization was present in 26% of 144 control patients with other heart diseases or normal hearts. Disorganization in these patients was usually limited in extent. In 7% of controls, abnormally arranged cells occupied 5% or more of the tissue section. The average area of septum disorganized was 31 .+-. 3% (mean .+-. SEM [standard error of the mean]) in patients with hypertrophic cardiomyopathy and 1.5 .+-. 0.6% in controls (P < 0.001). While ventricular septal disorganization is not pathognomonic of hypertrophic cardiomyopathy, widespread distribution of this abnormality is a very sensitive and specific histologic marker for this disease.