LONG-TERM TREATMENT OF HYPERCHOLESTEROLEMIA WITH DIETARY FIBER
LONG-TERM TREATMENT OF HYPERCHOLESTEROLEMIA WITH DIETARY FIBER
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DOI：
10.1016/0002-9343(94)90344-1
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发表时间：
1994-12-01
影响因子：
5.9
通讯作者：
HOWARD, WJ
中科院分区：
文献类型：
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作者：
HUNNINGHAKE, DB;MILLER, VT;HOWARD, WJ
目得：为了评估长期治疗（36至51周）与混合物的膳食纤维（瓜尔豆胶，果胶，大豆，豌豆，玉米麸皮）管理twice-day.PATIENTS和METHODS：59例中度高胆固醇血症谁完成了15周，安慰剂对照研究的膳食纤维进行了额外的36周的治疗与20克/天的纤维。在开始治疗前和治疗期间，对受试者进行国家胆固醇教育计划（NCEP）第一步饮食的咨询和监测。在额外的36周的治疗过程中的脂蛋白值的变化分析考虑到了体重，饮食和其他变量的变化，可能会影响到对treatment.RESULTS：无论是甘油三酯或高密度脂蛋白胆固醇（HDL-C）的水平没有显着的影响。治疗期间总胆固醇（TC）和低密度脂蛋白胆固醇（LDL-C）水平以及LDL/HDL比值显著降低。治疗51周后，TC、LDL-C和LDL/HDL比值较基线的平均百分比降低约为5%、9%和11%。治疗3周后的变化是明显的，最大的减少发生在第15周的treatment.CONCLUSIONS：对于受试者的第一步饮食谁遵守治疗方案，适度的降胆固醇作用的纤维持续整个36至51周的治疗期间。
PURPOSE: TO evaluate the hypocholesterolemic effects of long-term treatment (36 to 51 weeks) with a mixture of dietary fibers (guar gum, pectin, soy, pea, corn bran) administered twice a day.PATIENTS AND METHODS: Fifty-nine subjects with moderate hypercholesterolemia who completed a 15-week, placebo-controlled study with the dietary fiber were treated for an additional 36 weeks with 20 g/day of fiber. Subjects were counseled and monitored on a National Cholesterol Education Program (NCEP) Step-One Diet before starting and during treatment. Analyses of changes in lipoprotein values during the additional 36 weeks of treatment took into account changes in weight, diet, and other variables that might have affected the response to treatment.RESULTS: There were no significant effects on the levels of either triglycerides or high-density lipoprotein cholesterol (HDL-C). Levels of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) and the LDL/HDL ratio were significantly reduced during treatment. The mean percentage reductions from baseline after 51 weeks of treatment were approximately 5% for TC, 9% for LDL-C, and 11% for the LDL/HDL ratio. Changes were apparent after 3 weeks of treatment, with the maximum reductions occurring by the 15th week of treatment.CONCLUSIONS: For subjects on a Step-One Diet who complied with the treatment regimen, the moderate cholesterol-lowering effects of the fiber persisted throughout the 36-to-51 week treatment period.