Morphea-like reaction to D-penicillamine therapy.
Morphea-like reaction to D-penicillamine therapy.
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D-青霉胺治疗出现硬斑病样反应。
DOI：
10.1136/ard.40.1.42
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发表时间：
1981
影响因子：
27.4
通讯作者：
B. Gostelow
中科院分区：
文献类型：
--
作者：
R. Bernstein;M. Hall;B. Gostelow
我们报告的情况下，一个48岁的妇女谁开发的硬斑样斑块后，1年的治疗与D-青霉胺在250毫克，每天为血清阴性的类风湿性关节炎型糜烂。皮疹开始为躯干上的几个红色发痒的斑块;这些斑块在约3个月内变得增厚和有光泽。组织学表现为真皮纤维化增加，真皮毛细血管周围有炎性浸润。然而，表皮变化不是典型的硬斑病。停用青霉胺后几个月内不再出现新的病变，到1年时，所有斑块均为苍白无斑。
We report the case of a 48-year-old woman who developed morphea-like plaques after 1 year of treatment with D-penicillamine at 250 mg daily for a seronegative erosive arthritis of rheumatoid type. The rash began as several red itchy patches on the trunk; these became thickened and shiny over about 3 months. The histological appearance was of increased dermal fibrosis with an inflammatory infiltrate round dermal capillaries. However, epidermal changes were not typical of morphea. New lesions ceased to appear within a few months of stopping penicillamine, and by 1 year all the plaques were pale and symptomless.