Using GeneWise in the Drosophila annotation experiment
Using GeneWise in the Drosophila annotation experiment
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DOI：
10.1101/gr.10.4.547
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发表时间：
2000-04-01
期刊：
影响因子：
7
通讯作者：
Durbin, R
中科院分区：
文献类型：
--
作者：
Birney, E;Durbin, R
将基因预测和同源性搜索相结合的GeneWise方法应用于果蝇（Drosophilamelanogaster）2.9Mb区域。来自基因组注释评估项目（GASP）的结果表明，GeneWise提供了相当准确的基因预测。进一步的研究表明，许多来自GeneWise的不正确的基因预测是由于具有有效蛋白质编码基因的转座子，其余的情况是假基因或可能的注释疏忽。
The GeneWise method For combining gene prediction and homology searches was applied to the 2.9-Mb region from Drosophila melanogaster. The results from the Genome Annotation Assessment Project (GASP) showed that GeneWise provided reasonably accurate gene predictions. Further investigation indicates that many of the incorrect gene predictions From GeneWise were due to transposons with valid protein-coding genes and the remaining cases are pseudogenes or possible annotation oversights.