Favorable Long-Term Oncologic Outcomes of Hepatocellular Carcinoma Following Laparoscopic Liver Resection
Favorable Long-Term Oncologic Outcomes of Hepatocellular Carcinoma Following Laparoscopic Liver Resection
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DOI：
10.1089/lap.2015.0534
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发表时间：
2016-06-01
影响因子：
1.3
通讯作者：
Paik, Kwang Yeol
中科院分区：
文献类型：
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作者：
Ahn, Sanghyun;Cho, Ara;Paik, Kwang Yeol
背景资料：关于肝细胞癌（HCC）患者腹腔镜肝切除术（LLR）与开放性肝切除术（OLR）的长期肿瘤学结局的报告很少。本研究的目的是比较LLR和OLR作为治疗HCC patients.Patients和方法的长期结果：共125例患者被纳入本研究（32例接受LLR和93例接受OLR）。根据手术方法对数据进行分类。主要终点是无病生存期和总生存期。次要终点是肝癌LLR的手术结局。结果：LLR组中包膜侵犯更常见（P=.001）。中位随访时间为48个月（1-188个月）。在死亡率和发病率方面，两组之间没有显著差异。LLR组的住院天数较短（P=.042）。LLR和OLR组HCC的5年无病生存率分别为40.9%和47.2%（P= 0.376）。LLR组和OLR组HCC的总体5年生存率分别为96.4%和96.7%（P= 0.748）。结论：我们对肿瘤学方面的长期分析证实了LLR与OLR相比在HCC患者中的安全性。
Background: Reports on the long-term oncologic outcomes of laparoscopic liver resection (LLR) compared to open liver resection (OLR) in patients with hepatocellular carcinoma (HCC) are rare. The aim of this study was to compare the long-term outcomes of LLR and OLR as a treatment for HCC patients.Patients and Methods: A total of 125 patients were included in the study (32 patients underwent LLR and 93 underwent OLR). Data were categorized according to operation methods. The primary endpoints were disease-free survival and overall survival. The secondary endpoints were surgical outcomes of LLR for HCC.Results: Capsular invasion was more frequent in the LLR group (P=.001). The median follow-up period was 48 months (1-188 month). There were no significant differences between the two groups regarding mortality and morbidity. Hospitalization days were shorter in the LLR group (P=.042). Disease-free 5-year survival of HCC was 40.9% and 47.2% in the LLR and OLR group, respectively (P=.376). Overall 5-year survival for HCC was 96.4% and 96.7% for the LLR and OLR group, respectively (P=.748).Conclusion: Our long-term analysis on oncologic aspects confirms the safety of LLR compared to OLR in HCC patients.