Role of the Endothelium in Neonatal Diseases.
Role of the Endothelium in Neonatal Diseases.
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DOI：
10.5005/jp-journals-11002-0025
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发表时间：
2022-01
期刊：
影响因子：
--
通讯作者：
Maheshwari, Akhil
中科院分区：
文献类型：
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作者：
Mezu-Ndubuisi, Olachi J;Maheshwari, Akhil
在胎儿和新生儿的生理和病理过程中，大多数器官，内皮细胞是已知的发挥关键作用。虽然内皮细胞是体内最普遍的细胞类型之一，但其与血管壁的紧密粘附使得研究其多样的功能和结构变得困难。在这篇文章中，我们回顾了内皮细胞的起源，并探讨了它们在结构，功能，发育变化方面的异质性，以及它们在炎症和感染性疾病中的作用。我们还试图评估内皮细胞在新生儿疾病中尚未开发的治疗潜力。本文包括各种同行评议的研究，包括我们的研究，以及从EMBASE，PubMed和Scopus进行的广泛数据库文献检索。
In both fetal and neonatal physiologic and pathologic processes in most organs, endothelial cells are known to play critical roles. Although the endothelium is one of the most ubiquitous cell type in the body, the tight adherence to the blood vessel wall has made it difficult to study their diverse function and structure. In this article, we have reviewed endothelial cell origins and explored their heterogeneity in terms of structure, function, developmental changes, and their role in inflammatory and infectious diseases. We have also attempted to evaluate the untapped therapeutic potentials of endothelial cells in neonatal disease. This article comprises various peer-reviewed studies, including ours, and an extensive database literature search from EMBASE, PubMed, and Scopus.