Fertility-Sparing Treatment for Early-Stage Cervical, Ovarian, and Endometrial Malignancies.
Fertility-Sparing Treatment for Early-Stage Cervical, Ovarian, and Endometrial Malignancies.
复制标题
早期宫颈，卵巢和子宫内膜恶性肿瘤的生育能力治疗。
DOI：
10.1097/aog.0000000000004163
复制
发表时间：
2020-12
影响因子：
7.2
通讯作者：
Rauh-Hain JA
中科院分区：
文献类型：
--
作者：
Nitecki R;Woodard T;Rauh-Hain JA
大约20%的妇科恶性肿瘤是在育龄妇女中诊断出来的，标准的外科治疗通常会阻止未来的生育能力。在早期疾病中，关于保留生育力的医疗和手术方法的共同决策可能会使精心挑选的患者有机会追求他们的家庭建设目标，而不会影响长期生存。虽然未来的生育能力是年轻女性癌症患者的重要考虑因素，但保留生育能力的手术率仍然很低。此外，由于生育保留治疗后的妊娠率和结局数据有限，因此建议患者实现现实的期望具有挑战性。本文综述了早期妇科恶性肿瘤保留生育能力方法的关键肿瘤学结局，并强调了这一人群的妊娠结局。与接受妇科恶性肿瘤治疗的育龄患者讨论保留生育能力的方法是很重要的。
Approximately 20% of gynecologic malignancies are diagnosed in reproductive-age women, and standard-of-care surgical treatment often precludes future fertility. In early-stage disease, shared decision making about fertility-sparing medical and surgical approaches may give well-selected patients the opportunity to pursue their family-building goals without compromising long-term survival. While future fertility is an important consideration for young women with cancer, rates of fertility-sparing procedures remain low. Moreover, as data on pregnancy rates and outcomes after fertility-sparing treatments are limited, it is challenging to counsel patients on realistic expectations. This review examines the critical oncologic outcomes of fertility-sparing approaches in early-stage gynecologic malignancies, and highlights pregnancy outcomes in this population. Fertility-sparing approaches are important to discuss with appropriate reproductive-age patients being treated for a gynecologic malignancy.