Blood Harmane (1-Methyl-9H-Pyrido[3,4-b]indole) and Mercury in Essential Tremor: A Population-Based, Environmental Epidemiology Study in the Faroe Islands.
Blood Harmane (1-Methyl-9H-Pyrido[3,4-b]indole) and Mercury in Essential Tremor: A Population-Based, Environmental Epidemiology Study in the Faroe Islands.
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特发性震颤中的血液 Harmane（1-甲基-9H-吡啶并[3,4-b]吲哚）和汞：法罗群岛基于人群的环境流行病学研究。
DOI：
10.1159/000505874
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发表时间：
2020
影响因子：
5.7
通讯作者：
Petersen,MariaSkaalum
中科院分区：
文献类型：
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作者：
Louis,ElanD;Eliasen,EinaH;Ferrer,Monica;IglesiasHernandez,Daniella;Gaini,Shahin;Jiang,Wendy;Zheng,Wei;Nielsen,Flemming;Petersen,MariaSkaalum
背景：原发性震颤(ET)是最常见的神经系统疾病之一。人们对其环境决定因素知之甚少。Harmane(1-甲基-9H-吡啶并[3，4-b]吲哚)，一种饮食中产生震颤的神经毒素，在纽约和马德里的几项研究中被认为与ET有关。汞，也是一种产生震颤的神经毒素，尚未在ET中进行研究。目的：在这项以人群为基础的病例对照研究中，我们直接测量了ET患者和对照组的血汞浓度(HA)和血汞浓度(Hg)。结果：虽然诊断组间无统计学差异，但确诊ET组(4.13 g-10/mL)和可能ET组(2.28 g-10/mL)的中位数(HA)分别是对照组(1.53 g-10/mL)的2.7倍和1.5倍。小样本量是一个限制。对于明确的ET和对照组，p=0.126。(HG)组间相似。结论：明确和可能的ET患者的HA水平略有升高。这些数据与之前发表的数据相似，并可能将这种神经毒素和ET之间的病因学联系延伸到第三个地点。这项研究不支持汞和ET之间的联系。
Background:Essential tremor (ET) is among the most prevalent neurological diseases. Its environmental determinants are poorly understood. Harmane (1-methyl-9H-pyrido[3, 4-b]indole), a dietary tremor-producing neurotoxin, has been linked to ET in a few studies in New York and Madrid. Mercury, also a tremor-producing neurotoxin, has not been studied in ET. The Faroe Islands have been the focus of epidemiological investigations of numerous neurological disorders.Objective:In this population-based, case-control study, we directly measured blood harmane concentrations (HA) and blood mercury concentrations (Hg) in ET cases and controls.Methods:In total, 1,328 Faroese adults were screened; 26 ET cases were identified whose (HA) and (Hg) were compared to 197 controls.Results:Although there were no statistically significant differences between diagnostic groups, median (HA) was 2.7× higher in definite ET (4.13 g–10/mL) and 1.5× higher in probable ET (2.28 g–10/mL) than controls (1.53 g–10/mL). Small sample size was a limitation. For definite ET versus controls,p= 0.126. (Hg) were similar between groups.Conclusions:We demonstrated marginally elevated (HA) in definite and probable ET. These data are similar to those previously published and possibly extend etiological links between this neurotoxin and ET to a third locale. The study did not support a link between mercury and ET.