Outcome of cadaver kidney transplantation in 23 patients with type 2 diabetes mellitus.
Outcome of cadaver kidney transplantation in 23 patients with type 2 diabetes mellitus.
复制标题
23例2型糖尿病患者尸体肾移植的结果。
DOI：
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复制
发表时间：
2001
影响因子：
--
通讯作者：
Y. Pirson
中科院分区：
文献类型：
--
作者：
A. V. Mieghem;C. Fonck;W. Coosemans;B. Vandeleene;Y. Vanrenterghem;J. Squifflet;Y. Pirson
背景
BACKGROUND
Type 2 diabetes mellitus (DM) is a growing cause of end-stage renal failure worldwide. Yet, only a minority of type 2 diabetics are considered today for kidney transplantation (KT). The scarcity of data on the outcome of such patients after KT prompted us to review our experience.
METHODS
Between 1 January 1983 and 30 June 1996, 23 patients with type 2 DM received a first cadaver KT at a mean age of 57+/-9 (41-73) years, after a dialysis period ranging from 5 to 72 (mean 25+/-18) months. Only nine patients had a history of coronary and/or peripheral vascular disease before KT. All were given cyclosporin- or tacrolimus-based immunosuppression. Post-KT follow-up ranged from 4 to 181 (mean 70+/-38) months. Outcome analysis focused on the impact of cardiovascular complications.
RESULTS
Patient survival at 1, 5 and 8 years was 91, 83 and 76% respectively. Death was due to infection in three patients and to a cardiovascular event in two. The actuarial risk of coronary, cerebrovascular, peripheral vascular, and any cardiovascular event after KT was 14, 13, 9 and 30% at 1 year, 20, 13, 50 and 58% at 5 years, and 20, 46, 66 and 72% at 8 years respectively. Post-KT hospital readmissions averaged 10 days/patient-year and were mostly related to the management of peripheral vascular disease.
CONCLUSION
KT is an excellent therapeutic option for selected patients with type 2 DM. Peripheral vascular disease is the leading cause of morbidity following KT. KT should be considered in type 2 diabetics with a low/medium cardiovascular risk.
影响因子：
158.5
作者：
Hariharan, S;Johnson, CP;Stablein, D
通讯作者：
Stablein, D
糖尿病移植候选人的动脉粥样硬化血管并发症。
DOI：
10.1016/s0272-6386(97)90344-9
发表时间：
1997
期刊：
American journal of kidney diseases : the official journal of the National Kidney Foundation
影响因子：
--
作者：
Manske,CL;Wilson,RF;Wang,Y;Thomas,W
通讯作者：
Thomas,W
影响因子：
158.5
作者：
Wolfe, RA;Ashby, VB;Port, FK
通讯作者：
Port, FK