PATHOGENESIS OF TULAREMIA IN MONKEYS AEROGENICALLY EXPOSED TO FRANCISELLA-TULARENSIS 425
PATHOGENESIS OF TULAREMIA IN MONKEYS AEROGENICALLY EXPOSED TO FRANCISELLA-TULARENSIS 425
复制标题
DOI：
10.1128/iai.5.5.734-744.1972
复制
发表时间：
1972-01-01
影响因子：
3.1
通讯作者：
EIGELSBACH, HT
中科院分区：
文献类型：
--
作者：
SCHRICKER, RL;HALL, WC;EIGELSBACH, HT
在恒河猴（Macaca mulatta）组中研究了土拉菌病的发病机制，恒河猴吸入10至106种不同剂量的土拉菌弗朗西斯菌425，这是一种对小白鼠剧毒但对家兔剧毒较弱的菌株。平均潜伏期为3至6天，随后急性疾病持续5至11天，随后大多数动物康复。吸入剂量越高，潜伏期越短，急性疾病越长、越严重，最高剂量时死亡率为18%。菌株425在肺部繁殖，扩散到局部淋巴结，成为全身感染。与吸入的微生物数量无关，动物暴露后第7天达到组织中最大细菌数量。暴露2个月后，6个组织中的任何一个组织都无法恢复tularensis。最显著的组织变化发生在肺部；这些包括液化坏死灶、小叶实变、胸腔积液和粘连。数据表明，菌株425的吸入剂量决定了细菌在肺部的最大生长，这反过来影响了通常自限性肺炎和全身感染的严重程度。虽然猴子对兔热病的抵抗力不如人，但这种实验动物感染f后。tularensis425为通常在欧洲和亚洲观察到的自限性人肺土拉菌病提供了一个有用的模型，但在北美的程度较小。
The pathogenesis of tularemia was studied in groups of rhesus monkeys (Macaca mulatta) that inhaled graded 10-fold doses ranging from 10 through 106organisms ofFrancisella tularensis425, a strain highly virulent for the white mouse but of reduced virulence for the domestic rabbit. Mean incubation periods ranged from 3 to 6 days followed by acute illness lasting 5 to 11 days with subsequent recovery of most animals. The higher inhaled doses resulted in shorter incubation periods, longer and more severe acute illnesses, and 18% mortality at the highest dose. Strain 425 multiplied in the lungs, disseminated to the regional lymph nodes, and became systemic. Maximal bacterial populations in tissues were reached by the 7th day after exposure of the animals regardless of the number of organisms inhaled.F. tularensiswas no longer recoverable from any of six tissues examined 2 months after exposure. The most significant tissue changes occurred in the lungs; these consisted of foci of liquefaction necrosis, lobular consolidation, and pleural effusion and adhesions. The data indicate that the inhaled dose of strain 425 determined the maximal growth of the organism in the lungs which in turn influenced the severity of the usually self-limiting pneumonia and systemic infection. Although the monkey is less resistant to tularemia than is man, this laboratory animal when infected withF. tularensis425 provides a useful model for the self-limiting type of human pulmonary tularemia usually observed in Europe and Asia but to a lesser extent in North America.