Oxide hemostatic activity
Oxide hemostatic activity
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DOI：
10.1021/ja061717a
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发表时间：
2006-07-05
影响因子：
15
通讯作者：
Stucky, Galen D.
中科院分区：
文献类型：
--
作者：
Ostomel, Todd A.;Shi, Qihui;Stucky, Galen D.
高表面积止血生物活性玻璃的可调体外凝血活性通过血栓弹性仪（一种用于定量凝血过程中血液变化的临床仪器）进行评估。本文描述了与止血生物活性玻璃和球形止血生物活性玻璃的新制备相关的止血趋势，以及类似的含硅和含钙氧化物，并与Si:Ca比、Ca2+可用性和配位环境、孔隙度、ΔHHydration和表面积相关。止血生物活性玻璃是一种具有优异止血效果的新材料，在化学上与传统用于骨生长的生物玻璃不同。
The tunable in vitro blood clotting activity of high-surface-area hemostatic bioactive glass is evaluated by Thromboelastograph, a clinical instrument for quantifying changes in blood during coagulation. The hemostatic trends associated with hemostatic bioactive glass and a new preparation of spherical hemostatic bioactive glass, along with similar Si- and Ca-containing oxides, are described and related to Si:Ca ratios, Ca2+availability and coordination environment, porosity, ΔHHydration, and surface area. Hemostatic bioactive glass is a new material with an excellent efficacy for inducing hemostasis and is chemically distinct from the traditional bioglass employed for bone growth.