Early life programming of obesity and metabolic disease
Early life programming of obesity and metabolic disease
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DOI：
10.1016/j.physbeh.2007.11.017
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发表时间：
2008-04-22
影响因子：
2.9
通讯作者：
Ozanne, S. E.
中科院分区：
文献类型：
--
作者：
Cottrell, E. C.;Ozanne, S. E.
越来越明显的是，早年经历的状况对个人的长期健康起着重要作用。在子宫内和出生后相对可塑性的关键时期，由于发育受损、过度或不平衡而导致的发育变化可能导致生理系统的永久性编程。随着肥胖率、相关代谢疾病和心血管疾病的持续上升，能量平衡的调节是一个受到特别关注的领域。近几十年来，在了解代谢组织和生理系统的发育方式以及早期生活事件和营养对这些过程的影响方面取得了很大进展。很明显，在人类群体中，一些人在面对肥胖环境时能够更好地保持适当的体重。动物模型已被广泛用于研究饮食诱导肥胖(DIO)和能量平衡调节受损的不同易感性，并揭示了可能涉及的关键途径。下面概述的调节能量动态平衡的通路的改变，可能是早期生命发育受扰后编程效应的候选对象。(C)2007 Elsevier Inc.保留所有权利。
It is becoming increasingly apparent that conditions experienced in early life play an important role in the long-term health of individuals. Alterations in development due to impaired, excessive or imbalanced growth, both in utero and during critical periods of relative plasticity beyond birth, can lead to the permanent programming of physiological systems. The regulation of energy balance is one area that is receiving particular attention, as rates of obesity and associated metabolic and cardiovascular disease continue to rise. Over recent decades, much progress has been made toward understanding the way in which metabolic tissues and physiological systems develop, and the impact of early life events and nutrition on these processes. It is apparent within human populations that some individuals are better able to maintain an appropriate body weight in the face of an obesogenic environment. Animal models have been widely used for the investigation of differential susceptibility to diet-induced obesity (DIO) and impaired energy balance regulation, and are shedding light on key pathways that may be involved. Alterations in pathways mediating energy homeostasis, outlined below, are likely candidates for programming effects following disturbed growth in early life. (C) 2007 Elsevier Inc. All rights reserved.