Cutaneous angiosarcoma with thrombocytopenia.
Cutaneous angiosarcoma with thrombocytopenia.
复制标题
皮肤血管肉瘤伴血小板减少症。
DOI：
10.1053/jd.1999.v40.a95645
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发表时间：
1999
影响因子：
13.8
通讯作者：
K. Nishioka
中科院分区：
文献类型：
--
作者：
T. Satoh;Yuichi Takahashi;H. Yokozeki;I. Katayama;K. Nishioka
3例头面部皮肤血管肉瘤患者出现血小板减少。随着原发灶或转移灶的迅速增大，血小板计数突然下降。未检测到抗血小板抗体和血小板相关免疫球蛋白。血清中β-血栓球蛋白和血小板第4因子水平的升高表明，血小板被破坏并在肿瘤的血管床内被消耗。肿瘤细胞表面PECAM-1的显著表达可能参与了肿瘤内血小板的聚集和消耗。我们认为，血管肉瘤患者早发性血小板减少的突然发展可能预示着原发肿瘤的快速生长或预示着转移性疾病的发展。
Thrombocytopenia was observed in 3 patients with cutaneous angiosarcoma of the scalp and face. A sudden decrease in the platelet count occurred in association with rapid enlargement of primary or metastatic lesions. Neither antiplatelet antibody nor platelet-associated IgG was detected. Increased serum levels of beta-thromboglobulin and platelet factor 4 indicated that platelets were destroyed and consumed within the vascular bed of the tumor. Prominent PECAM-1 expression on tumor cells may be involved in intratumoral platelet aggregation and consumption. We suggest that the sudden development of profund thrombocytopenia in patients with angiosarcoma may suggest either rapid growth of the primary tumor or herald the development of metastatic disease.
通过持续输注使用白细胞介素 2 进行免疫治疗期间出现血小板减少症。
DOI：
10.1016/0002-9343(90)90343-c
发表时间：
1990
期刊：
The American journal of medicine
影响因子：
--
作者：
Paciucci,PA;Mandeli,J;Oleksowicz,L;Ameglio,F;Holland,JF
通讯作者：
Holland,JF
纤溶、血小板减少和凝血异常使高剂量白细胞介素 2 免疫治疗变得复杂。
DOI：
--
发表时间：
1991
期刊：
The Journal of laboratory and clinical medicine
影响因子：
--
作者：
Fleischmann,JD;Shingleton,WB;Gallagher,C;Ratnoff,OD;Chahine,A
通讯作者：
Chahine,A