Transdermal nicotine effects on attention
Transdermal nicotine effects on attention
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DOI：
10.1007/s002130050750
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发表时间：
1998-11-01
影响因子：
3.4
通讯作者：
Rose, JE
中科院分区：
文献类型：
--
作者：
Levin, ED;Conners, CK;Rose, JE
尼古丁已被证明可以改善吸烟者的注意力，并减轻阿尔茨海默病患者，精神分裂症患者和注意力缺陷/多动症（ADHD）成人的注意力缺陷，目前的研究旨在确定通过透皮贴剂给予尼古丁是否会改善无注意力缺陷的非吸烟成人的注意力。受试者以平衡双盲方式接受尼古丁和安慰剂暴露。治疗效果的测量包括情绪状态（POMS），Conners的计算机化的注意力持续表现测试（CPT）和计算机化的间隔计时任务。受试者在早晨接受7 mg/天尼古丁透皮贴剂给药，持续4.5 h。尼古丁显着增加自我感知的活力，POMS测试测量。在CPT上，尼古丁显着减少了遗漏错误的数量，而不会导致委员会或正确命中反应时间的错误增加。尼古丁还显着降低了命中反应时间和注意力的综合措施的方差。这项研究表明，除了减少注意力障碍外，通过透皮贴剂给予尼古丁还可以改善正常成年非吸烟者的注意力。
Nicotine has been shown to improve attentiveness in smokers and attenuate attentional deficits in Alzheimer's disease patients, schizophrenics and adults with attention-deficit/hyperactivity disorder (ADHD), The current study was conducted to determine whether nicotine administered via transdermal patches would improve attentiveness in non-smoking adults without attentional deficits. The subjects underwent the nicotine and placebo exposure in a counterbalanced double-blind manner. Measures of treatment effect included the Profile of Mood States (POMS), Conners' computerized Continuous Performance Test (CPT) of attentiveness and a computerized interval-timing task. The subjects were administered a 7 mg/day nicotine transdermal patch for 4.5 h during a morning session. Nicotine significantly increased self-perceived vigor as measured by the POMS test. On the CPT, nicotine significantly decreased the number of errors of omission without causing increases in either errors of commission or correct hit reaction time. Nicotine also significantly decreased the variance of hit reaction time and the composite measure of attentiveness. This study shows that, in addition to reducing attentional impairment, nicotine administered via transdermal patches can improve attentiveness in normal adult nonsmokers.