Variability of pacemaker rhythm in a detailed model of cardiac sinoatrial node cells
Variability of pacemaker rhythm in a detailed model of cardiac sinoatrial node cells
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DOI：
10.1109/tencon.2010.5686665
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发表时间：
2010-11
期刊：
影响因子：
--
通讯作者：
Zhenxing Pan;S. Doi
中科院分区：
文献类型：
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作者：
Zhenxing Pan;S. Doi
窦房结(心脏起搏器)细胞自发产生周期性电信号(动作电位)，动作电位的产生与其细胞膜上的各种离子通道密切相关。离子通道的异常导致严重的窦性心律失常，治疗此类疾病通常采用对离子通道有影响的药物。本文利用窦房结细胞的Zhang模型，研究了起搏器节律(动作电位产生频率)与离子通道的关系。张氏模型由Hodgkin-Huxley非线性常微分方程组描述，其参数值依赖于窦房结的区域(周边或中心)。我们分析了张模型的分叉结构，考察了起搏器节律的变化及其对周围和中心细胞离子通道电导变化的敏感性。此外，将这些结果与另一种窦房结细胞模型(Yanagihara-Noma-Irisawa模型)的结果进行了比较。以上结果有望为窦性心律失常的治疗提供参考。
The sinoatrial node (cardiac pacemaker) cell spontaneously generates periodic electrical signals (action potentials), and the action potential generation is deeply related to various ion channels in its cell membrane. The abnormalities of ion channels cause serious sinus arrhythmia, and such diseases are usually treated by applying drugs which have effects on ion channels. This paper uses the Zhang model of sinoatrial node cells to investigate the relation between pacemaker rhythm (frequency of action potential generation) and ion channels. The Zhang model is described by the Hodgkin-Huxley-type nonlinear ordinary differential equations, and its parameter values depend on the region (periphery or center) of the sinoatrial node. We analyze the bifurcation structure of the Zhang model, and examine the variabilities of pacemaker rhythm and its sensitivities on conductance changes of ion channels for both periphery and center cells. Moreover, these results are compared to the previous results of another sinoatrial node cell model (Yanagihara-Noma-Irisawa model). The above results are expected to be useful in the treatment of sinus arrhythmia.