Neuronal Activity in the Caudal Frontal Eye Fields of Monkeys during Memory-Based Smooth Pursuit Eye Movements: Comparison with the Supplementary Eye Fields
Neuronal Activity in the Caudal Frontal Eye Fields of Monkeys during Memory-Based Smooth Pursuit Eye Movements: Comparison with the Supplementary Eye Fields
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DOI：
10.1093/cercor/bhq261
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发表时间：
2011-08-01
期刊：
影响因子：
3.7
通讯作者：
Fukushima, Kikuro
中科院分区：
文献类型：
--
作者：
Fukushima, Junko;Akao, Teppei;Fukushima, Kikuro
最近，我们研究了基于记忆的平滑追求过程中预测追求的神经元基质，发现辅助视场（SEFs）包含视觉运动方向、不追求决策和准备追求的编码评估和记忆信号。为了确定这些信号是否是SEF独有的，我们检测了2只猕猴尾侧额叶眼（FEFs） 185个任务相关神经元的放电。视觉运动记忆和不动信号也存在于尾侧FEF中，但与尾侧FEF相比，编码这些信号的神经元比例明显较低。特别是，与SEF神经元不同，尾侧FEF神经元的定向视觉运动反应呈指数衰减。相比之下，尾侧FEF中编码定向追逐眼球运动的神经元比例明显高于尾侧FEF。与SEF失活不同的是，向尾侧FEF注射muscimol不会引起方向错误或不走错误，但会降低追逐过程中的眼速度，导致无法补偿正弦追逐过程中的反应延迟。这些结果表明，这两个区域在所代表的信号和化学失活的影响方面存在显著差异，这表明尾侧FEF主要参与产生平滑追踪眼球运动的运动命令。
Recently, we examined the neuronal substrate of predictive pursuit during memory-based smooth pursuit and found that supplementary eye fields (SEFs) contain signals coding assessment and memory of visual motion direction, decision not-to-pursue ("no-go"), and preparation for pursuit. To determine whether these signals were unique to the SEF, we examined the discharge of 185 task-related neurons in the caudal frontal eye fields (FEFs) in 2 macaques. Visual motion memory and no-go signals were also present in the caudal FEF but compared with those in the SEF, the percentage of neurons coding these signals was significantly lower. In particular, unlike SEF neurons, directional visual motion responses of caudal FEF neurons decayed exponentially. In contrast, the percentage of neurons coding directional pursuit eye movements was significantly higher in the caudal FEF than in the SEF. Unlike SEF inactivation, muscimol injection into the caudal FEF did not induce direction errors or no-go errors but decreased eye velocity during pursuit causing an inability to compensate for the response delays during sinusoidal pursuit. These results indicate significant differences between the 2 regions in the signals represented and in the effects of chemical inactivation suggesting that the caudal FEF is primarily involved in generating motor commands for smooth-pursuit eye movements.