The Road Map for Megakaryopoietic Lineage from Hematopoietic Stem/Progenitor Cells.
The Road Map for Megakaryopoietic Lineage from Hematopoietic Stem/Progenitor Cells.
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DOI：
10.1002/sctm.16-0490
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发表时间：
2017-08
影响因子：
6
通讯作者：
Chiba S
中科院分区：
文献类型：
--
作者：
Nishikii H;Kurita N;Chiba S
巨核细胞（Mgk）是被指定产生血小板的终末分化的血细胞，而造血干细胞（HSC）是保留多能性以产生所有种类的血细胞的最未分化的血细胞。因此，这两种细胞类型分别位于造血层级的底部和顶部。尽管存在这种距离，但它们共享几个重要的细胞表面分子以及转录因子。在传统的逐步分化模型中，HSC逐渐失去自我更新能力并分化为多能祖细胞（multipotent progenitor，MPP），这是髓系和淋巴系的第一个分支点。在该模型中，普通髓系祖细胞可以分化成双能Mgk/红系祖细胞（MEP），并且MEP最终分化成单能成熟Mgk。然而，最近有报道称，HSC和MPP区室中的亚群显示出Mgk偏倚的分化潜力。这些报告意味着应该讨论HSC至Mgk分化途径的修订。本文就近年来造血干细胞向巨噬细胞分化的研究进展作一综述，并对今后的研究方向作一展望。干细胞转化医学2017;6：1661-1665
Megakaryocytes (Mgks) are terminally differentiated blood cells specified to produce platelets, whereas hematopoietic stem cells (HSCs) are the most undifferentiated blood cells that retain multipotency to produce all kinds of blood cells. As such, these two cell types reside at the bottom and the top of the hematopoietic hierarchy, respectively. In spite of this distance, they share several important cell surface molecules as well as transcription factors. In the conventional step‐wise differentiation model, HSCs gradually lose their self‐renewal capacity and differentiate into multipotent progenitors (MPPs), which is the first branch point of myeloid and lymphoid lineage. In this model, common myeloid progenitors can differentiate into bipotent Mgk/erythroid progenitors (MEPs), and MEPs eventually differentiate into unipotent mature Mgks. However, it has been recently reported that a subpopulation within the HSC and MPP compartments demonstrates an Mgk‐biased differentiation potential. These reports imply that revisions to the HSC‐to‐Mgk differentiation pathway should be discussed. In this review, we summarize recent findings about Mgk differentiation from HSCs and discuss future directions in this research field. Stem Cells Translational Medicine 2017;6:1661–1665
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影响因子：
16.6
作者：
Grover A;Sanjuan-Pla A;Thongjuea S;Carrelha J;Giustacchini A;Gambardella A;Macaulay I;Mancini E;Luis TC;Mead A;Jacobsen SE;Nerlov C
通讯作者：
Nerlov C
DOI：
10.1002/stem.1985
发表时间：
2015-07
期刊：
Stem cells (Dayton, Ohio)
影响因子：
--
作者：
Nishikii H;Kanazawa Y;Umemoto T;Goltsev Y;Matsuzaki Y;Matsushita K;Yamato M;Nolan GP;Negrin R;Chiba S
通讯作者：
Chiba S
影响因子：
64.5
作者：
Kiel, MJ;Yilmaz, ÖH;Morrison, SJ
通讯作者：
Morrison, SJ
DOI：
10.1073/pnas.95.3.1195
发表时间：
1998-02-03
影响因子：
11.1
作者：
Kimura, S;Roberts, AW;Alexander, WS
通讯作者：
Alexander, WS
影响因子：
64.5
作者：
Adolfsson, J;Månsson, R;Jacobsen, SEW
通讯作者：
Jacobsen, SEW