Quantitating genetic and nongenetic factors that determine plasma sex steroid variation in normal male twins.
Quantitating genetic and nongenetic factors that determine plasma sex steroid variation in normal male twins.
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定量确定正常男性双胞胎血浆性类固醇变异的遗传和非遗传因素。
DOI：
10.1016/0026-0495(86)90020-x
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
West,DW
中科院分区：
文献类型：
--
作者：
Meikle,AW;Bishop,DT;Stringham,JD;West,DW
我们观察到，家族因素对一般人群和前列腺癌家族男性血浆性类固醇含量有决定性影响。本文研究了75对正常男性同卵双生子和88对异卵双生子血浆性类固醇含量和作用的遗传和非遗传家族因素的作用。通过测量十种血液蛋白质和酶来确定接合性。双胞胎组间睾酮（T）、双氢睾酮（DHT）、雌二醇（E2）、雌酮（E1）和3α-雄甾烷酮葡萄糖醛酸苷（3α-diol G）、游离T、LH、FSH、SHBG、年龄和肥胖程度的平均血浆值均相似。家族因素（P< 0.01）占同卵双生子血浆激素水平变化的50%或以上（3α-diol G，84%; T DHT，70%; T，63%; E1，63%;游离T，61%; E2，57%; DHT，56%; LH，55%; FSH，54%），SHBG为30%。除SHBG外，MZ双胞胎的家庭影响均大于DZ双胞胎。血浆中激素水平变化的遗传力由方程2 [r MZ（组内相关）-r DZ]确定。基因调节25%至76%的血浆激素含量的总变化，除了DHT（12%）和SHBG（< 1%）。通过观察血浆3α-diol G含量的48%的遗传效应，表明组织DHT形成的遗传调节。这些观察结果表明，遗传因素在调节正常男性的雌激素和睾酮水平以及组织中DHT的产生方面做出了重要贡献。
We have observed that familial factors have a decided influence on the plasma content of sex steroids in men both in the general population and in men of families with prostatic cancer. The contribution of genetic and nongenetic familial factors on the variation of plasma sex steroid content and action has now been investigated in 75 pairs of normal male monozygotic (MZ) twins and 88 pairs of dizygotic (DZ) twins. Zygosity was determined by measuring ten blood proteins and enzymes. The mean plasma values for testosterone (T), dihydrotestosterone (DHT), estradiol (E 2), estrone (E 1), and 3α-androstanediol glucuronide (3α-diol G), free T, LH, FSH, SHBG, age, and degree of adiposity were all similar between the groups of twins. Familial factors (P< 0.01) accounted for 50% or more of the variation in plasma hormone levels in MZ twins (3α-diol G, 84%; T DHT, 70%; T, 63%; E 1, 63%; free T, 61%; E 2, 57%; DHT, 56%; LH, 55%; and FSH, 54%) except for SHBG, which was 30%. The familial influence was greater in MZ twins than in DZ twins for all measurements except for SHBG. The heritability of the variation of hormone levels in plasma was determined from the equation: 2 [r MZ (intraclass correlation)-r DZ]. Genes regulate 25% to 76% of the total variation of plasma content of the hormones except for DHT (12%) and SHBG (< 1%). Genetic regulation of tissue DHT formation was suggested by observing a 48% genetic effect on the plasma content of 3α-diol G. These observations suggest that genetic factors make major contributions in regulating estrogen and testosterone levels and tissue DHT production in normal men.