ARE ESTROGENS INVOLVED IN FALLING SPERM COUNTS AND DISORDERS OF THE MALE REPRODUCTIVE-TRACT
ARE ESTROGENS INVOLVED IN FALLING SPERM COUNTS AND DISORDERS OF THE MALE REPRODUCTIVE-TRACT
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DOI：
10.1016/0140-6736(93)90953-e
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发表时间：
1993-05-29
期刊：
影响因子：
168.9
通讯作者：
SKAKKEBAEK, NE
中科院分区：
文献类型：
--
作者：
SHARPE, RM;SKAKKEBAEK, NE
在过去的30-50年里，男性生殖道发育障碍的发生率增加了一倍多，而精子数量减少了大约一半。在怀孕期间接触己烯雌酚(DES)的妇女的儿子中也会出现类似的异常，在怀孕期间短暂接触外源性雌激素/DES可以在动物身上诱导出类似的异常。我们认为，人类男性生殖异常发生率的增加可能与子宫内雌激素暴露增加有关，并确定了这种暴露可能发生的机制。
The incidence of disorders of development of the male reproductive tract has more than doubled in the past 30-50 years while sperm counts have declined by about half. Similar abnormalities occur in the sons of women exposed to diethylstilbestrol (DES) during pregnancy and can be induced in animals by brief exposure to exogenous oestrogen/DES during pregnancy. We argue that the increasing incidence of reproductive abnormalities in the human male may be related to increased oestrogen exposure in utero, and identify mechanisms by which this exposure could occur.