Sexual orientation, health risk factors, and physical functioning in the Nurses' Health Study II
Sexual orientation, health risk factors, and physical functioning in the Nurses' Health Study II
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DOI：
10.1089/jwh.2004.13.1033
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发表时间：
2004-11-01
影响因子：
3.5
通讯作者：
Spiegelman, D
中科院分区：
文献类型：
--
作者：
Case, P;Austin, SB;Spiegelman, D
目的：研究性取向与乳腺癌危险因素、心血管疾病 (CVD) 危险因素、心理健康状况和健康相关功能之间的关联。方法：我们将护士健康研究 11 (NHSII) 中报告女同性恋或双性恋取向的参与者与报告异性恋取向的参与者进行比较，并以异性恋者作为所有比较的参考组。通过对整个队列的分布进行标准化，根据年龄、血统和居住地区的分布差异来调整健康行为和状况的患病率。使用二项式回归和对数链接函数计算多变量患病率，以将女同性恋和双性恋与异性恋进行比较。使用根据整个队列的分布标准化的连续量表来测量健康状况的平均值。通过多元线性回归测试比较女同性恋、双性恋和异性恋的平均值差异。所有比较均根据年龄、血统和居住地区进行了调整。 结果：根据 1995 年 90,823 名 32-51 岁女性的信息，与异性恋女性相比，那些报告性取向为女同性恋的女性 (n = 694) 的乳腺癌危险因素的患病率更高，包括未生育和每日饮酒量高。女同性恋者心血管疾病的多种危险因素的患病率也较高，包括较高的体重指数（BMI）和当前吸烟的患病率较高。女同性恋者更有可能患有抑郁症和使用抗抑郁药。女同性恋和双性恋女性的健康风险因素的主要结果相似 (n = 317)。结论：女同性恋和双性恋女性的乳腺癌、心血管疾病以及心理健康和功能结果不佳等几个重要风险因素的患病率较高。大多数这些风险因素是可以改变的，适当的干预措施可以在改善女同性恋和双性恋女性的健康状况方面发挥重要作用。
Objectives: To examine associations between sexual orientation and breast cancer risk factors, cardiovascular disease (CVD) risk factors, mental health status, and health-related functioning.'Methods: We compared participants in the Nurses' Health Study 11 (NHSII) reporting a lesbian or bisexual orientation with those reporting a heterosexual orientation, with heterosexuals serving as the reference group for all comparisons. Prevalence of health behaviors and conditions was adjusted for differences in the distribution of age, ancestry, and region of residence by standardizing to the distribution of the overall cohort. Multivariate prevalence ratios were calculated to compare lesbians and bisexuals with heterosexuals using binomial regression with the log link function. Means of health conditions were measured using continuous scales standardized to the distribution of the overall cohort. Differences in means comparing lesbians and bisexuals with heterosexuals were tested by multivariate linear regression. All comparisons were adjusted for age, ancestry, and region of residence.Results: Based on information from 90,823 women aged 32-51 in 1995, those reporting a sexual orientation of lesbian (n = 694) had a higher prevalence of risk factors for breast cancer, including nulliparity and high daily alcohol intake, compared with heterosexual women. Lesbians also had a higher prevalence of several risk factors for CVD, including higher body mass index (BMI) and elevated prevalence of current smoking. Lesbians were more likely to report depression and the use of antidepressants. Key results for health risk factors were similar for lesbians and bisexual women (n = 317).Conclusions: Lesbian and bisexual women were found to have a higher prevalence of several important risk factors for breast cancer, CVD, and poor mental health and functioning outcomes. Most of these risk factors are modifiable, and appropriate interventions could play an important role in improving the health status of lesbian and bisexual women.