The Combined Quantification and Interpretation of Multiple Quantitative Magnetic Resonance Imaging Metrics Enlightens Longitudinal Changes Compatible with Brain Repair in Relapsing-Remitting Multiple Sclerosis Patients.
The Combined Quantification and Interpretation of Multiple Quantitative Magnetic Resonance Imaging Metrics Enlightens Longitudinal Changes Compatible with Brain Repair in Relapsing-Remitting Multiple Sclerosis Patients.
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DOI：
10.3389/fneur.2017.00506
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发表时间：
2017
影响因子：
3.4
通讯作者：
Granziera C
中科院分区：
文献类型：
--
作者：
Bonnier G;Maréchal B;Fartaria MJ;Falkowskiy P;Marques JP;Simioni S;Schluep M;Du Pasquier R;Thiran JP;Krueger G;Granziera C
定量和半定量MRI（qMRI）指标为与脑炎症、变性和修复相容的病理性脑变化提供互补特异性和差异灵敏度。此外，具有重叠元素的高级磁共振成像（MRI）度量放大了真实的组织相关信息并限制了测量噪声。在这项工作中，我们结合多种先进的MRI参数，以评估局灶性和弥漫性脑变化超过2年的一组早期复发缓解型MS患者。30例病程少于5年的复发缓解型MS患者和9例健康受试者在基线和2年后接受了3 T MRI，包括T1、T2、T2* 弛豫和磁化传递成像。为了评估外观正常（NA）组织和病变的纵向变化，我们使用方差分析和Bonferroni校正进行多重比较。多变量线性回归用于评估临床结果与病变和NA组织的多参数MRI变化之间的相关性。在患者中，我们测量到NA白色物质的平均T2弛豫时间显著纵向减少（p = 0.005），苍白球的T1弛豫时间减少（p < 0.05），这与水肿重吸收和/或铁沉积相一致。在对照组中未观察到qMRI指标的纵向变化。在MS病变中，我们测量到T1弛豫时间的减少（p值< 2.2e−16）和MTR的显著增加（p值<1 e −6），这表明修复机制，如髓鞘再生，轴突密度增加和/或神经胶质增生。最后，先进的MRI指标的演变-而不是病变或脑体积的变化-与运动和认知测试分数的演变相关（R2> 0.4，p < 0.05）。总之，多种高级MRI的组合提供了与组织病理学研究所建议的早期MS阶段的局灶性和弥漫性脑修复相容的变化的证据。
Quantitative and semi-quantitative MRI (qMRI) metrics provide complementary specificity and differential sensitivity to pathological brain changes compatible with brain inflammation, degeneration, and repair. Moreover, advanced magnetic resonance imaging (MRI) metrics with overlapping elements amplify the true tissue-related information and limit measurement noise. In this work, we combined multiple advanced MRI parameters to assess focal and diffuse brain changes over 2 years in a group of early-stage relapsing-remitting MS patients. Thirty relapsing-remitting MS patients with less than 5 years disease duration and nine healthy subjects underwent 3T MRI at baseline and after 2 years including T1, T2, T2* relaxometry, and magnetization transfer imaging. To assess longitudinal changes in normal-appearing (NA) tissue and lesions, we used analyses of variance and Bonferroni correction for multiple comparisons. Multivariate linear regression was used to assess the correlation between clinical outcome and multiparametric MRI changes in lesions and NA tissue. In patients, we measured a significant longitudinal decrease of mean T2 relaxation times in NA white matter (p = 0.005) and a decrease of T1 relaxation times in the pallidum (p < 0.05), which are compatible with edema reabsorption and/or iron deposition. No longitudinal changes in qMRI metrics were observed in controls. In MS lesions, we measured a decrease in T1 relaxation time (p-value < 2.2e−16) and a significant increase in MTR (p-value < 1e−6), suggesting repair mechanisms, such as remyelination, increased axonal density, and/or a gliosis. Last, the evolution of advanced MRI metrics—and not changes in lesions or brain volume—were correlated to motor and cognitive tests scores evolution (Adj-R2 > 0.4, p < 0.05). In summary, the combination of multiple advanced MRI provided evidence of changes compatible with focal and diffuse brain repair at early MS stages as suggested by histopathological studies.
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影响因子：
3.3
作者：
Callaghan, Martina F.;Helms, Gunther;Lutti, Antoine;Mohammadi, Siawoosh;Weiskopf, Nikolaus
通讯作者：
Weiskopf, Nikolaus
DOI：
10.1177/135245850100700409
发表时间：
2001-08-01
期刊：
MULTIPLE SCLEROSIS
影响因子：
--
作者：
Boringa, JB;Lazeron, RHC;Polman, CH
通讯作者：
Polman, CH
影响因子：
3.7
作者：
Metere R;Kober T;Möller HE;Schäfer A
通讯作者：
Schäfer A
通过松弛模型建模合成定量MRI。
影响因子：
2.9
作者：
Callaghan, Martina F.;Mohammadi, Siawoosh;Weiskopf, Nikolaus
通讯作者：
Weiskopf, Nikolaus
影响因子：
11.2
作者：
Chen, Jacqueline T.;Collins, D. Louis;Arnold, Douglas L.
通讯作者：
Arnold, Douglas L.