A Novel Protein for the Bioremediation of Gadolinium Waste.
A Novel Protein for the Bioremediation of Gadolinium Waste.
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用于钆废物生物修复的新型蛋白质。
DOI：
10.1101/2023.01.05.522788
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Gilad,AssafA
中科院分区：
文献类型：
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作者：
Lee,HarveyD;Grady,ConnorJ;Krell,Katie;Strebeck,Cooper;Good,NathanM;Martinez-Gomez,NCecilia;Gilad,AssafA
每年有数百吨钆基造影剂（GBCA）被倾倒到环境中。尽管大环GBCA与其线性对应物相比表现出上级稳定性，但我们发现螯合物的结构完整性对紫外光敏感，而与构型无关。在这项研究中，我们提出了一种称为GLamouR的合成蛋白，它以增强的方式结合并报告钆。然后，我们探索从MRI患者尿液中提取钆作为钆污染的预防措施，并研究采用具有成本效益的生物修复技术处理受污染水体的可行性。基于有希望的结果，我们预计GLamouR等蛋白质可用于检测和开采钆以外的稀土元素，并希望扩大此类应用的生物工具箱。
Several hundreds of tons of gadolinium‐based contrast agents (GBCAs) are being dumped into the environment every year. Although macrocyclic GBCAs exhibit superior stability compared to their linear counterparts, we have found that the structural integrity of chelates is susceptible to ultraviolet light, regardless of configuration. In this study, we present a synthetic protein termed GLamouR that binds and reports gadolinium in an intensiometric manner. We then explore the extraction of gadolinium from MRI patient urine as a preventative measure for gadolinium pollution and investigate the viability of employing cost‐effective bioremediation techniques for treating contaminated water bodies. Based on promising results, we anticipate proteins such as GLamouR can be used for detecting and mining rare earth elements beyond gadolinium and hope to expand the biological toolbox for such applications.