Osteopontin prevents monocyte recirculation and apoptosis
Osteopontin prevents monocyte recirculation and apoptosis
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DOI：
10.1189/jlb.1106711
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发表时间：
2007-06-01
影响因子：
5.5
通讯作者：
Fox, Howard S.
中科院分区：
文献类型：
--
作者：
Burdo, Tricia H.;Wood, Malcolm R.;Fox, Howard S.
单核/巨噬细胞系的细胞已被证明是HIV-1在中枢神经系统内高效复制的主要目标。此外，HIV-1相关性痴呆(HAD)已被证明与大脑中巨噬细胞的丰度有关。虽然单核细胞进入大脑的增加被认为是启动这一过程的原因，但阻止巨噬细胞从大脑外流的机制和防止巨噬细胞死亡的手段也可能有助于细胞积累。我们假设骨桥蛋白(OPN)参与了神经艾滋病患者脑内巨噬细胞的聚集。使用体外模型系统，我们已经证明了OPN在巨噬细胞聚集的两个不同方面的作用：防止再循环和保护细胞凋亡。在这些独特的机制中，OPN有助于巨噬细胞在脑内的存活和积聚，而脑内是HAD的病理底物。
Cells of the monocyte/macrophage lineage have been shown to be the principal targets for productive HIV-1 replication within the CNS. In addition, HIV-1-associated dementia (HAD) has been shown to correlate with macrophage abundance in the brain. Although increased entry of monocytes into the brain is thought to initiate this process, mechanisms that prevent macrophage egress from the brain and means that prevent macrophage death may also contribute to cell accumulation. We hypothesized that osteopontin (OPN) was involved in the accumulation of macrophages in the brain in neuroAIDS. Using in vitro model systems, we have demonstrated the role of OPN in two distinct aspects of macrophage accumulation: prevention from recirculation and protection from apoptosis. In these unique mechanisms, OPN would aid in macrophage survival and accumulation in the brain, the pathological substrate of HAD.