Transcription factors in the development of myeloid cells
Transcription factors in the development of myeloid cells
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骨髓细胞发育中的转录因子
DOI：
10.11406/rinketsu.56.1861
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
黒滝 大翼
中科院分区：
文献类型：
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作者：
田村 智彦;小泉 真一;黒滝 大翼
造血干细胞产生具有不同功能的各种类型的血细胞，尽管这些不同类型的细胞具有本质上相同的基因组序列。这种细胞类型多样性的基础是通过转录因子调控建立特定的基因表达模式。转录因子识别并结合靶基因中的特定核苷酸序列，招募染色质修饰剂来改变这些基因的表观遗传状态，从而控制其表达。这些过程的失调会导致白血病等疾病。由于染色质免疫沉淀测序（ChIP-seq）和RNA-seq等高通量实验技术的快速发展，转录因子的研究正在进入一个新的时代。在这篇综述中，我们更新了目前关于骨髓细胞，特别是单核吞噬细胞（即单核/巨噬细胞和树突状细胞）的发育途径的知识，以及它们发育所需的转录因子。我们随后概述了髓系转录因子调节其靶基因的合作和拮抗机制，重点是染色质生物学。
Hematopoietic stem cells give rise to various blood cell types with diverse functions, although these different cell types harbor essentially identical genome sequences. The basis for this cell type diversity is the establishment of specific gene expression patterns through transcription factor regulation. Transcription factors recognize and bind to specific nucleotide sequences in target genes and recruit chromatin modifiers to alter the epigenetic status of these genes, thereby controlling their expression. Dysregulation of these processes can cause diseases such as leukemia. Due to rapid advances in high-throughput experimental techniques including chromatin immunoprecipitation-sequencing (ChIP-seq) and RNA-seq, the study of transcription factors is now entering a new era. In this review, we update the current knowledge of developmental pathways in myeloid cells, particularly mononuclear phagocytes (ie, monocytes/macrophages and dendritic cells), and the transcription factors known to be required for their development. We subsequently provide an overview of the cooperative and antagonistic mechanisms by which the myeloid transcription factors regulate their target genes, with an emphasis on chromatin biology.