Long-term potentiation as a substrate for memory: Evidence from studies of amygdaloid plasticity and Pavlovian fear conditioning
Long-term potentiation as a substrate for memory: Evidence from studies of amygdaloid plasticity and Pavlovian fear conditioning
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DOI：
10.1002/hipo.10099
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发表时间：
2002-01-01
期刊：
影响因子：
3.5
通讯作者：
Maren, S
中科院分区：
文献类型：
--
作者：
Goosens, KA;Maren, S
最近的报道引起了人们对长时程增强（LTP）解释联想学习和记忆的能力的关注。在本文中，我们回顾了许多机制之间的相似之处，一种形式的联想学习，巴甫洛夫恐惧条件反射，杏仁核LTP。然后，我们解决许多批评LTP的框架内的恐惧条件反射。我们认为，LTP和行为之间的许多明显差异通常可以解释为未能认识到学习行为是由大脑结构的广泛网络中的多个突触支持的。我们的结论是，LTP仍然是一个可行的基板的记忆。(C)2002 Wiley-Liss，Inc.
Recent reports have raised concerns about the ability of long-term potentiation (LTP) to account for associative learning and memory. In this paper, we review the many mechanistic similarities between one form of associative learning, Pavlovian fear conditioning, and amygdaloid LTP. We then address many of the criticisms levied against LTP within the framework of fear conditioning. We believe that many of the apparent discrepancies between LTP and behavior can be generally accounted for by a failure to appreciate that learned behavior is supported by multiple synapses in an extensive network of brain structures. We conclude that LTP remains a viable substrate for memory. (C) 2002 Wiley-Liss, Inc.