Extremes of Lineage Plasticity in the Drosophila Brain
Extremes of Lineage Plasticity in the Drosophila Brain
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DOI：
10.1016/j.cub.2013.07.074
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发表时间：
2013-10-07
期刊：
影响因子：
9.2
通讯作者：
Lee, Tzumin
中科院分区：
文献类型：
--
作者：
Lin, Suewei;Marin, Elizabeth C.;Lee, Tzumin
神经可塑性的一个经常被忽视的方面是神经元组成的可塑性，其中特定类别的神经元的数量会根据环境和经验而改变。果蝇大脑具有几个特征明显的谱系，其中单个神经母细胞在发育过程中以定型序列产生多个神经元类别[1]。我们发现，在内在蘑菇体神经元谱系中，每个类别的数量是高度可塑的，这取决于时间命运转变的时间和成神经细胞增殖的速率。例如，蘑菇体成神经细胞循环可以在饥饿条件下继续，与依赖于反映生物体生长和发育的外在线索的时间命运转变脱钩。与此相反，触角叶谱系的增殖率与生物体发育密切相关，其时间命运的变化似乎是细胞周期依赖性的，这样，相同数量和类型的uniglomerular投射神经元支配触角叶以下各种扰动。我们认为，这种令人惊讶的差异，这些大脑谱系的可塑性是自适应的，考虑到他们各自的角色作为并行处理器与离散载体的嗅觉信息。
An often-overlooked aspect of neural plasticity is the plasticity of neuronal composition, in which the numbers of neurons of particular classes are altered in response to environment and experience. The Drosophila brain features several well-characterized lineages in which a single neuroblast gives rise to multiple neuronal classes in a stereotyped sequence during development [1]. We find that in the intrinsic mushroom body neuron lineage, the numbers for each class are highly plastic, depending on the timing of temporal fate transitions and the rate of neuroblast proliferation. For example, mushroom body neuroblast cycling can continue under starvation conditions, uncoupled from temporal fate transitions that depend on extrinsic cues reflecting organismal growth and development. In contrast, the proliferation rates of antennal lobe lineages are closely associated with organismal development, and their temporal fate changes appear to be cell cycle-dependent, such that the same numbers and types of uniglomerular projection neurons innervate the antennal lobe following various perturbations. We propose that this surprising difference in plasticity for these brain lineages is adaptive, given their respective roles as parallel processors versus discrete carriers of olfactory information.